p38α has an important role in antigen cross-presentation by dendritic cells  

作　　者：Yifan Zhou Jianfeng Wu Chunxiao Liu Xueheng Guo Xinyi Zhu Yuan Yao Yuhao Jiao Peng He Jiahuai Han Li Wu 

机构地区：[1]Institute for Immunology,School of Medicine,Tsinghua University,Beijing,100084,China [2]State Key Laboratory of Cellular Stress Biology,School of Life Sciences,Xiamen University,Xiamen,361005,Fujian,China [3]State Key Laboratory of Biomembrane,National Engineering Laboratory for Anti-tumor Therapeutics,School of Medicine,Tsinghua University,Beijing,100084,China [4]Tsinghua-Peking Joint Center for Life Sciences,Beijing,100084,China

出　　处：《Cellular & Molecular Immunology》2018年第3期246-259,共14页中国免疫学杂志（英文版）

基　　金：This work was supported by grants from the Chinese Ministry of Science and Technology National Major Scientific Research Program(2015CB943200);the Key Project Grant from the National Natural Science Foundation of China(31330027);the National Basic Research Program of China(2015CB553800);the Tsinghua Science Foundation(20111080963).

摘　　要：The role of the p38 signaling pathway in the innate and adaptive immune responses has been well documented,especially in inflammatory cytokine production by dendritic cells(DCs).However,whether the p38 signaling pathway affects the important antigen(Ag)presentation function of DCs remains largely unknown.In this study,we reported that the deletion of p38αresulted in an impaired cross-presentation ability of CD8^(+) conventional DCs(cDCs)and a reduction in the direct presentation ability of CD8−cDCs ex vivo.Further study revealed that p38αhad a crucial role in Ag processing by CD8^(+) cDCs but did not affect the Ag uptake or co-stimulation of T cells.Moreover,p38αdeficiency led to reduced cross-priming of T cells in vivo.The production of the IL-12p40 and IL-12p70 cytokines by p38α-deficient cDCs was also significantly reduced.Our study identified a new role for p38αin modulating the important antigen cross-presentation function of DCs.

关 键 词：antigen presentation CROSS-PRESENTATION dendritic cells p38α 

分 类 号：R73[医药卫生—肿瘤]