Revisiting GM-CSF as an adjuvant for therapeutic vaccines  

作　　者：Weidong Zhao Gan Zhao Bin Wang 

机构地区：[1]Key Laboratory of Medical Molecular Virology of the Ministry of Health and Ministry of Education,School of Basic Medical Sciences,Fudan University,Shanghai,200032,China [2]Department of Laboratory Medicine,Clinical Medicine College,Dali University,Dali 200032,China. [3]PhD,Key Laboratory of Medical Molecular Virology of the Ministry of Health and Ministry of Education,School of Basic Medical Sciences,Fudan University,131 Dong An Road,Shanghai,200032,China

出　　处：《Cellular & Molecular Immunology》2018年第2期187-189,共3页中国免疫学杂志（英文版）

基　　金：This work is supported by grants from the National Science and Technology Major Program of Infectious Diseases(2012ZX10002002004-001,2012ZX10004701 and 2013ZX10002001);the Natural Science Foundation of China(31430027 and 81672016)to BW;We thank Dr Yan Shi for his critical review and suggestions and Dr Douglas Lowrie for his proofreading.

摘　　要：Granulocyte macrophage colony stimulating factor(GM-CSF)is generally considered to be a proinflammatory cytokine;GM-CSF-based vaccines have been shown to elicit potent antitumor and antiviral immune responses in preclinical experiments.In clinical trials,however,these effects were not as robust and sometimes even contradicted the findings from animal models.In this commentary,we aim to discuss the latest advances in this field,hoping that an upto-date and comprehensive understanding of this molecule will help others design effective GM-CSF-based strategies for antiviral and anticancer vaccines.

关 键 词：vaccines CLINICAL stimulating 

分 类 号：R73[医药卫生—肿瘤]