Liver-resident NK cells and their potential functions  

作　　者：Hui Peng Rui Sun 

机构地区：[1]Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease,School of Life Sciences and Medical Center,University of Science and Technology of China,Hefei,Anhui 230027,China

出　　处：《Cellular & Molecular Immunology》2017年第11期890-894,共5页中国免疫学杂志（英文版）

基　　金：by the Natural Science Foundation of China(#81761128013,81571522,91642105,81361120388,31300727,91542114,91442112,91542000 and 81330071);the Ministry of Science and Technology of China(973 Basic Science Project 2013CB944902).

摘　　要：Natural killer(NK)cells represent a heterogeneous population of innate lymphocytes with phenotypically and functionally distinct subsets.In particular,recent studies have identified a unique subset of NK cells residing within the liver that are maintained as tissue-resident cells,confer antigen-specific memory responses and exhibit different phenotypical and developmental characteristics compared with conventional NK(cNK)cells.These findings have encouraged researchers to uncover tissue-resident NK cells at other sites,and detailed analyses have revealed that these tissue-resident NK cells share many similarities with liver-resident NK cells and tissue-resident memory T cells.Here,we present a brief historical perspective on the discovery of liver-resident NK cells and discuss their relationship to cNK cells and other emerging NK cell subsets and their potential functions.

关 键 词：POTENTIAL maintained finding 

分 类 号：R73[医药卫生—肿瘤]