The biomarkers of immune dysregulation and inflammation response in Parkinson disease  

作　　者：Li Chen Mingshu Mo Guangning Li Luan Cen Lei Wei Yousheng Xiao Xiang Chen Shaomin Li Xinling Yang Shaogang Qu Pingyi Xu 

机构地区：[1]Department of Neurology,The First Affiliated Hospital of Guangzhou Medical University,Guangdong 510120,China [2]Department of Neurology,The First Affiliated Hospital of Sun Yat-sen University,Guangdong 510080,China [3]Department of Neurology,The Third Affiliated Hospital of Sun Yat-sen University,Guangdong 510082,China [4]Ann Romney Center for Neurologic Disease,Brigham and Women’s Hospital,Harvard Medical School,Boston,MA 02115,USA [5]Department of Neurology,The Third Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China [6]Department of Blood Transfusion,The Fifth Affiliated Hospital,Southern Medical University,Guangzhou,Guangdong 510900,China [7]Department of Neurology,The Affiliated Huadu Hospital of Southern Medical University,Guangzhou 510800,China

出　　处：《Translational Neurodegeneration》2016年第1期131-136,共6页转化神经变性病（英文）

基　　金：This review was supported by research grants from the State Key Development Program for Basic Research of China(2011CB510000);the National Natural Science Foundation of China(81271428,81471292,U1503222 and 81430021);the keypoint Science Foundation of Guangdong of China(2015A030311021);a grant supported by technology project of Guangzhou(201604020152);a grant supported by assisting research project of science and technology for Xinjiang(201591160).

摘　　要：Parkinson’s disease(PD)is referring to the multi-systemicα-synucleinopathy with Lewy bodies deposited in midbrain.In ageing,the environmental and genetic factors work together and overactive major histocompatibility complex pathway to regulate immune reactions in central nerve system which resulting in neural degeneration,especially in dopaminergic neurons.As a series of biomarkers,the human leukocyte antigen genes with its related proteomics play cortical roles on the antigen presentation of major histocompatibility complex molecules to stimulate the differentiation of T lymphocytes and i-proteasome activities under their immune response to the PD-related environmental alteration and genetic variation.Furthermore,dopaminergic drugs change the biological characteristic of T lymphatic cells,affect theα-synuclein presentation pathway,and inhibit T lymphatic cells to release cytotoxicity in PD development.Taking together,the serum inflammatory factors and blood T cells are involved in the immune dysregulation of PD and inspected as the potential clinic biomarkers for PD prediction.

关 键 词：Parkinson’s disease α-synucleinopathy INFLAMMATION Biomarkers 

分 类 号：R74[医药卫生—神经病学与精神病学]