Euglobal-IIIa, a novel acylphloroglucinol-sesquiterpene derivative from Eucalyptus robusta: absolute structure and cytotoxicity  

作　　者：Li-Yan PENG Juan HE Gang XU Xing-De WU Liao-Bin DONG Xiu GAO Xiao CHENG Jia SU Yan LI Qin-Shi ZHAO 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China

出　　处：《Natural Products and Bioprospecting》2011年第2期101-103,共3页应用天然产物（英文）

基　　金：This work was financially supported by the National Natural Science Foundation of China(No.90813004 and No.2009312311024);the 973 Program(No.2009CB522300);the State Key Laboratory of Phytochemistry and Plant Resources in West China(P2010-ZZ05).

摘　　要：Euglobal-IIIa (1), a novel acylphloroglucinol-sesquiterpene derivative, and a known analogue, have been isolated from leaves of Eucalyptus robusta. The structures was elucidated by extensive spectroscopic data and by comparison with data reported in literature, while the absolute configuration of 1 was determined by the X-ray diffraction analysis. Compound 1 exhibited comparable cytotoxicity with that of cisplatin against five human cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480 with IC50 values of 15.7, 15.5, 17.6, 14.3, and 21.8 μM, respectively.

关 键 词：Eucalyptus robusta acylphloroglucinol-sesquiterpene absolute structure CYTOTOXICITY 

分 类 号：R73[医药卫生—肿瘤]