IFN-inducible p47 GTPases display differential responses to Schistosoma japonicum acute infection  

作　　者：Xuesong Chen Xiaotang Du Meijuan Zhang Donghui Zhang Minjun Ji Guanling Wu 

机构地区：[1]Department of Pathogen Biology and Immunology,Nanjing Medical University,Nanjing,China [2]Jiangsu Province Key Laboratory of Modern Pathogen Biology,Nanjing,China

出　　处：《Cellular & Molecular Immunology》2010年第1期69-76,共8页中国免疫学杂志（英文版）

基　　金：This work was supported by the National Basic Research Program of China(973 Program 2007CB513106);the National Science Foundation of China(NSFC)(Project No.30430600 and No.30872368).

摘　　要：Interferon gamma induced GTPase(IGTP)(also named lrgm3)and interferon gamma inducible protein 47(IRG-47)(also named lIrgd)are interferon(IFN)-inducible p47 GTPases that have been shown to regulate host resistance to intracellular pathogens.Little knowledge has been known about the role of p47 GTPases in host responses against extracellular pathogens.To investigate possible roles of IGTP and IRG-47 in the course of Schistosoma japonicum infection,IGTP and IRG-47 knockout and wild-type(WT)mice were challenged with cercariae of S.japonicum,and host responses were analyzed.At the acute stage of S.japonicum infection,mice that lacked IGTP displayed similar parasite burden and pathological damage to WT mice.Importantly,S.japonicum-infected lRG-47-deficient mice,in contrast to IGTP-deficient mice and WT mice,showed significantly reduced worms and lower egg-burden,but intense granulomatous reaction evoked by schistosome eggs in peripheral parts of liver lobes.In addition,upregulation of inflammation-related gene expression was observed in the spleen of IRG-47-deficient mice using oligonucleotide microarrays,in which multiple pathways of cytokine-cytokine receptor interaction,T-cell receptor signaling,complement,coagulation cascades and cell adhesion molecules were highlighted.Taken together,these data suggest that IGTP and IRG-47 might have distinct features that were differentially required for resistance to S.japonicum.

关 键 词：acute infection IMMUNITY p47 GTPase Schistosoma japonicum 

分 类 号：R73[医药卫生—肿瘤]