Non-cirrhotic hepatocellular carcinoma in chronic viral hepatitis: Current insights and advancements  

作　　者：Abhilash Perisetti Hemant Goyal Rachana Yendala Ragesh B Thandassery Emmanouil Giorgakis 

机构地区：[1]Department of Internal Medicine,Division of Gastroenterology,University of Arkansas for Medical Sciences,Little Rock,AR 72205,United States [2]Department of Internal Medicine,Macon University School of Medicine,Macon,GA 31207,United States [3]Department of Hematology and Oncology,Conway Regional Health System(CRHS),Conway,AR 72034,United States [4]Department of Gastroenterology and Hepatology,Central Arkansas Veterans Healthcare System,Little Rock,AR 72205,United States [5]Department of Transplant,University of Arkansas for Medical Sciences Little Rock,AR 72205,United States

出　　处：《World Journal of Gastroenterology》2021年第24期3466-3482,共17页世界胃肠病学杂志（英文版）

摘　　要：Primary liver cancers carry significant morbidity and mortality.Hepatocellular carcinoma(HCC)develops within the hepatic parenchyma and is the most common malignancy originating from the liver.Although 80%of HCCs develop within background cirrhosis,20%may arise in a non-cirrhotic milieu and are referred to non-cirrhotic-HCC(NCHCC).NCHCC is often diagnosed late due to lack of surveillance.In addition,the rising prevalence of non-alcoholic fatty liver disease and diabetes mellitus have increased the risk of developing HCC on noncirrhotic patients.Viral infections such as chronic Hepatitis B and less often chronic hepatitis C with advance fibrosis are associated with NCHCC.NCHCC individuals may have Hepatitis B core antibodies and occult HBV infection,signifying the role of Hepatitis B infection in NCHCC.Given the effectiveness of current antiviral therapies,surgical techniques and locoregional treatment options,nowadays such patients have more options and potential for cure.However,these lesions need early identification with diagnostic models and multiple surveillance strategies to improve overall outcomes.Better understanding of the NCHCC risk factors,tumorigenesis,diagnostic tools and treatment options are critical to improving prognosis and overall outcomes on these patients.In this review,we aim to discuss NCHCC epidemiology,risk factors,and pathogenesis,and elaborate on NCHCC diagnosis and treatment strategies.

关 键 词：Cirrhosis Hepatic fibrosis Non-alcoholic liver disease Primary liver cancer Hepatocellular carcinoma HEPATOMA Liver cancer Hepatitis B virus Hepatitis C virus Liver resection Liver transplantation 

分 类 号：R575.1[医药卫生—消化系统]