HEPATOMA

作品数：334被引量：1426H指数：20
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HBXIP induces PARP1 via WTAP-mediated m^(6)A modification and CEBPA-activated transcription in cisplatin resistance to hepatoma
《Acta Pharmacologica Sinica》2024年第11期2405-2419,共15页Xue-li Fu Shi-man Guo Jia-qi Ma Fang-yuan Ma Xue Wang Yan-xin Tang Ye Li Wei-ying Zhang Li-hong Ye 
supported by the National Natural Science Foundation of China(82072943,China);the National Natural Science Foundation of China(82072929,China).
Poly(ADP-ribose)polymerase 1(PARP1)is a DNA-binding protein that is involved in various biological functions,including DNA damage repair and transcription regulation.It plays a crucial role in cisplatin resistance.Nev...
关键词：HBXIP m^(6)A PARP1 cisplatin resistance HEPATOMA 
EGF自分泌介导EMT对Morris Hepatoma 3924A肝癌细胞的影响
《山东第二医科大学学报》2024年第4期259-262,268,共5页沙天宇 胡若涵 王广志 宁厚法 
山东省自然科学基金面上项目(项目编号:ZR2020MH293);潍坊市科技发展计划项目(医学类)(项目编号:2022YX050)。
目的通过观察上皮细胞-间充质转化(EMT)相关蛋白表达变化探讨表皮生长因子(EGF)自分泌对Morris Hepatoma 3924A肝癌细胞的影响。方法制作Morris Hepatoma 3924A肝癌细胞CoCl_(2)缺氧模型。通过Western Blot分析EGF自分泌对肿瘤EMT相关...
关键词：表皮生长因子 上皮细胞-间充质转化 肝细胞肝癌 
鸡THRSP基因对LMH细胞脂质沉积的调控作用被引量：1
《农业生物技术学报》2024年第7期1596-1605,共10页刘世昊 魏志恒 姜新城 闫耀华 徐璐 郁建锋 顾志良 
江苏省自然科学基金(BK20191476);常熟理工学院2023大学生创业创新计划资助。
甲状腺激素应答spot 14(thyroid hormone responsive spot 14,THRSP)是一种转录调控因子,参与组织的脂类代谢调控。为探讨THRSP基因在鸡(Gallus gallus)脂质代谢中的作用及调控机制,本研究检测了THRSP基因在鸡12种组织中的表达情况;以...
关键词：鸡 甲状腺激素应答spot 14(THRSP) 脂质代谢 鸡肝癌细胞系LMH(Leghorn male hepatoma) 
3D bioprinting of in vitro porous hepatoma models:establishment,evaluation,and anticancer drug testing
《Bio-Design and Manufacturing》2024年第2期137-152,共16页Xiaoyuan Wang Zixian Liu Qianqian Duan Boye Zhang Yanyan Cao Zhizhong Shen Meng Li Yanfeng Xi Jianming Wang Shengbo Sang 
supported by the National Natural Science Foundation of China(Nos.51975400 and 62031022);Shanxi Provincial Key Medical Scientific Research Project(Nos.2020XM06 and 2021XM12);Fundamental Research Program of Shanxi Province(No.202103021224081);Shanxi Provincial Basic Research Project(Nos.202103021221006 and 202103021223040);Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(No.2021L044);Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(No.2022SX-TD026).
Traditional tumor models do not tend to accurately simulate tumor growth in vitro or enable personalized treatment and are particularly unable to discover more beneficial targeted drugs.To address this,this study desc...
关键词：3D bioprinting Hepatoma tumor models Drug screening Antitumor drug development 
Scope and caveats:Artificial intelligence in gastroenterology
《Artificial Intelligence in Gastroenterology》2024年第1期9-13,共5页Gumpeny Ramachandra Sridhar Atmakuri V Siva Prasad Gumpeny Lakshmi 
The use of Artificial intelligence(AI)has evolved from its mid-20th century origins to playing a pivotal tool in modern medicine.It leverages digital data and computational hardware for diverse applications,including ...
关键词：Machine learning Neural networks Diagnosis Work-flow ETHICS Image POLYPS HEPATOMA 
AZD1775 and anti-PD-1 antibody synergistically sensitize hepatoma to radiotherapy被引量：2
《Chinese Medical Journal》2024年第2期222-231,共10页Yichun Yin Jian Wang Junxuan Yi Kaiyue Zhang Zimeng Yin Shunzi Jin Baisong Zheng 
supported by grants from the Science and Technology Department of Jilin Province(No.YDZJ202201ZYTS590);the National Natural Science Foundation of China(No.82173454)
Background:Radiation(IR)-induced DNA damage triggers cell cycle arrest and has a suppressive effect on the tumor microenvironment(TME).Wee1,a cell cycle regulator,can eliminate G2/M arrest by phosphorylating cyclin-de...
关键词：HEPATOMA Radiation AZD1775 Anti-PD-1 antibody DNA damage Tumor microenvironment 
Aconite aqueous extract inhibits the growth of hepatocellular carcinoma through CCL2-dependent enhancement of natural killer cell infiltration
《Journal of Integrative Medicine》2023年第6期575-583,共9页Kang-di Yang Xu Zhang Ming-cong Shao Li-na Wang 
funded by the National Natural Science Foundation of China(No.81774244).
Objective:Aconite is a traditional Chinese herbal medicine that has been found to inhibit the development of liver cancer;however,its exact molecular mechanisms in this process remain unclear.This study explores how a...
关键词：ACONITE Natural killer cell Tumor infiltration Chemokine CC chemokine ligand 2 HEPATOMA 
An ever-increasing metabolic dysfunction-associated fatty liver disease-related hepatocellular carcinoma:what are problems and countermeasures?
《Hepatobiliary Surgery and Nutrition》2023年第6期941-944,共4页Shigeo Shimose Tsubasa Tsutsumi Dan Nakano Tomoya Sano Keisuke Amano Takumi Kawaguchi 
supported by AMED (Grant No.JP23fk0210090).
Hepatocellular carcinoma(HCC)is the third leading cause of cancer deaths worldwide(1).HCC has been classified into viral or non-viral HCC according to the etiology and the incidence of viral HCC is decreasing.In contr...
关键词：HEPATOMA hepatic steatosis metabolic syndrome viral hepatitis lenvatinib(LEN) 
Blue LED promotes the chemosensitivity of human hepatoma to Sorafenib by inducing DNA damage
《BIOCELL》2023年第8期1811-1820,共10页TONG WANG JINHUAN HONG JIAJIE XIE QIAN LIU JINRUI YUE XUTING HE SHIYU GE TAO LI GUOXIN LIU BENZHI CAI LINQIANG LI YE YUAN 
supported by grants from the National Key Research and Development Program of China(2017YFB0403802);the Outstanding Youth Project of the Natural Science Foundation of Heilongjiang Province(YQ2020H019);the Huaier Fund in 2023 from Chen Xiao-Ping Foundation for the Development of Science and Technology of Hubei Province.
Background:Phototherapies based on sunlight,infrared,ultraviolet,visible,and laser-based treatments present advantages like high curative effects,small invasion,and negligible adverse reactions in cancer treatment.We ...
关键词：Blue LED Irradiation Liver cancer DNA damage Chemotherapy resistance 
A Novel CA4P Polymeric Nanoparticle for Murine Hepatoma Therapy
《Chinese Journal of Polymer Science》2023年第8期1223-1229,I0007,共8页Zhi-Lin Liu Xi-Tong Ren Yue Huang Jia-Li Sun Xiao-Shuang Wang Meng-Fei Zheng Lin-Jie Cui Xue-Fei Zhang Zhao-Hui Tang 
financially supported by the Ministry of Science and Technology of China(No.2022YFE0110200);the Natural Science Foundation of Hunan Province of China(No.2021JJ30680);the National Natural Science Foundation of China(Nos.52203198,52025035 and 52103195)。
Combretastatin A4 phosphate(CA4P)is a potent vascular disrupting agent with good water solubility.However,it is only effective at high doses,which decreases clinical applicability.Herein,we designed stable CA4P polyme...
关键词：CA4P polymeric nanoparticle Cholesterol derivatives Vascular disrupting agent Phosphate-guanidine coordination Drug controlled release 
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