PD-L1在非小细胞肺癌中的表达及相关性  

Expression and Correlation Analysis of PD-L1 in Non-small Cell Lung Cancer

作　　者：刘志良[1] 黄先明[1] 张小芳[1] 罗庆丰[1] 韩春宾 吴锦涛 周祥武 LIU Zhiliang;HUANG Xianming;ZHANG Xiaofang(Jiangxi Cancer Hospital,Nanchang,330029)

机构地区：[1]江西省肿瘤医院,330029

出　　处：《实用癌症杂志》2021年第7期1095-1097,共3页The Practical Journal of Cancer

基　　金：江西省卫生健康委项目(编号:20203542)。

摘　　要：目的探讨程序性死亡配体-1(PD-L1)在非小细胞肺癌(NSCLC)中的表达与其临床病理参数的关系。方法采用免疫组织化学两步法检测80例NSCLC组织中PD-L1的表达与其临床病理参数的关系。结果NSCLC腺癌中PD-L1高表达28例(73.7%,28/38),鳞癌9例(34.6%,9/26),混合癌7例(43.8%,7/16),差异存在统计学意义(χ^(2)=9.661,P=0.002<0.05);淋巴结阳性患者中PD-L1高表达42例(60%,42/70),淋巴结阴性2例PD-L1高表达(20%,2/10),差异具有统计学意义(χ^(2)=5.657,P=0.017<0.05);有吸烟史患者中PD-L1高表达32例(74.4%,32/43),不吸烟的12例PD-L1高表达(32.4%,12/37),差异具有统计学意义(χ^(2)=14.165,P<0.01)。男性患者中PD-L1高表达32例(55.2%,32/58),女性12例(54.5%,12/22);>60岁患者中PD-L1高表达24例(60%,24/40),≤60岁患者20例(50%,20/40);高中分化患者中PD-L1高表达12例(46.2%,12/26),低分化32例(59.3%,32/54);肿瘤直径≥3 cm患者中PD-L1高表达13例(46.4%,13/28),肿瘤直径<3 cm患者31例(59.6%,31/52)。结论PD-L1高低表达在性别、年龄、分化情况及肿瘤直径上差异性不存在统计学意义,但在病理类型、有无淋巴结转移、有无吸烟史方面的差异有统计学意义。Objective To investigate the expression of programmed death ligand-1(PD-L1)in non-small cell lung cancer(NSCLC)and its relationship with clinicopathological parameters.Methods The expression of PD-L1 in 80 cases of NSCLC was detected by two-step immunohistochemistry.Results There were 28 cases(73.7%,28/38)with high expression of PD-L1 in NSCLC adenocarcinoma,9 cases(34.6%,9/26)in squamous cell carcinoma and 7 cases(43.8%,7/16)in mixed carcinoma.The difference was statistically significant(χ^(2)=9.661,P=0.002<0.05);There were 42 cases(60%,42/70)with high expression of PD-L1 in lymph node positive patients and 2 cases(20%,2/10)with negative lymph node(χ^(2)=5.657,P=0.017<0.05);There were 32 cases(74.4%,32/43)with high expression of PD-L1 in patients with smoking history and 12 cases(32.4%,12/37)without smoking.The difference was statistically significant(χ^(2)=14.165,P<0.01).PD-L1 was highly expressed in 32 male patients(55.2%,32/58)and 12 female patients(54.5%,12/22)PD-L1 was highly expressed in 24 patients(60%,24/40)aged 60 years and 20 patients(50%,20/40)aged less than 60 years;PD-L1 was highly expressed in 12 cases(46.2%,12/26)and poorly differentiated in 32 cases(59.3%,32/54);PD-L1 was highly expressed in 13 patients(46.4%,13/28)with tumor diameter≥3cm and 31 patients(59.6%,31/52)with tumor diameter<3cm.Conclusion There is no statistical significance between high and low PD-L1 expression in terms of gender,age,differentiation status and tumor diameter,but there are statistically significant differences in terms of type of pathology,presence or absence of lymph node metastasis,and presence or absence of smoking history.

关 键 词：PD-L1 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]