植物蛋白-益生菌复合制剂对小鼠铅毒性的缓解作用  

Alleviating effects of plant protein-probiotics preparation on lead toxicity in mice

作　　者：马申嫣[1] 王晶[1] 朱家民 曹江[1] 翟齐啸 张灏[1] 赵建新[1] 田丰伟[1] 陈卫[1] MA Shenyan;WANG Jing;ZHU Jiaming;CAO Jiang;ZHAI Qixiao;ZHANG Hao;ZHAO Jianxin;TIAN Fengwei;CHEN Wei(School of Food Science and Technology,Jiangnan University,Wuxi 214122,China)

机构地区：[1]江南大学食品学院,江苏无锡214122

出　　处：《食品与发酵工业》2021年第13期51-58,共8页Food and Fermentation Industries

摘　　要：铅在体内过量蓄积会引发严重的氧化应激以及神经毒害反应,目前常用的螯合剂对轻度铅中毒的缓解作用较小且有一定的副作用,不能长期使用。植物乳杆菌CCFM8661在前期研究中表现出了良好的铅毒性缓解能力,具有一定的应用前景。该研究通过对植物乳杆菌CCFM8661与植物蛋白进行复配,探究不同复配方式对小鼠铅毒性缓解能力的影响。结果表明,CCFM8661与植物蛋白复配能够显著增强铅毒性缓解能力。其中CCFM8661+大豆蛋白促进小鼠粪便铅排泄,降低组织铅含量及缓解肠道炎症的效果更显著,而CCFM8661+大米蛋白能显著缓解铅对神经系统的毒害及肝肾脏的氧化损伤。同时CCFM8661与2种植物蛋白复配均能更好缓解铅暴露导致的肠道菌群失调。这表明CCFM8661能够与植物蛋白进行复配,并作为一款具有排铅功能的复合膳食补充剂产品进入市场,弥补市场上关于此类产品的空白。Lead is a non-essential metal with cumulative toxicity.Excessive accumulation of lead may cause serious oxidative stress and neurotoxic reactions.At present,the commonly chelating agents have a little alleviating effect on mild lead toxicity with side effects.In previous studies,Lactobacillus plantarum CCFM8661 showed good ability to alleviate lead toxicity,which had a promising application prospect.In this study,L.plantarum CCFM8661 was formulated with two plant protein to explore the ability of alleviate lead toxicity.The results showed that plant protein-probiotics formulation could significantly enhance the ability of alleviate lead toxicity and could better alleviate the intestinal flora imbalance which caused by lead exposure.Strain CCFM8661+soybean protein could accelerate the excretion of fecal lead,reduce the concentration of tissue lead and alleviate intestinal inflammation,while strain CCFM8661+rice protein could significantly alleviate lead toxicity of nervous system and oxidative damage of liver and kidney.The results indicated that strain CCFM8661 could be used as a dietary supplement with the function of removing lead,which will make up for the blank of this kind of product.

关 键 词：铅毒性 植物乳杆菌 植物蛋白 复合配方 

分 类 号：TS201.2[轻工技术与工程—食品科学] TS201.4[轻工技术与工程—食品科学与工程]