Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus  

作　　者：Xu-Jie Qin Tong Shu Qian Yu Huan Yan Wei Ni Lin-Kun An Pan-Pan Li Yin-E Zhi Afsar Khan Hai-Yang Liu 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,People’s Republic of China [2]Yunnan Key Laboratory of Medicinal Chemistry,Kunming 650201,People’s Republic of China [3]University of Chinese Academy of Sciences,Beijing 100049,People’s Republic of China [4]Institute of Medicinal Chemistry and Chemical Biology,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,People’s Republic of China [5]Department of Chemistry,COMSATS Institute of Information Technology,Abbottabad 22060,Pakistan

出　　处：《Natural Products and Bioprospecting》2017年第4期315-321,共7页应用天然产物（英文）

基　　金：National Natural Science Foundation of China(Nos.31600283 and 31570363);fund of State Key Laboratory of Phytochemistry and Plant Resources in West China(No.P2017-ZZ04)from Kunming Institute of Botany,Chinese Academy of Sciences.

摘　　要：Callisalignenes G–I(1–3),three new meroterpenoids of b-triketone and monoterpene,along with two known analogues(4 and 5),were isolated from Callistemon salignus.Their structures and absolute configurations were unambiguously established by a combination of NMR and MS analysis and electronic circular dichroism(ECD)evidence.Callisalignenes H(2)and I(3)have a rare sec-butyl moiety at C-7.Meroterpenoids 1–3 exhibited cytotoxicity against HCT116 cells with IC50 values of 8.51±1.8,9.12±0.3,and 16.33±3.3 lM,respectively.

关 键 词：Callistemon salignus MYRTACEAE MEROTERPENOIDS CYTOTOXICITY 

分 类 号：O62[理学—有机化学]