Immune plexins and semaphorins: old proteins, new immune functions  

作　　者：Kelly Roney Eda Holl Jenny Ting 

机构地区：[1]University of Chapel Hill,Department of Microbiology and Immunology,22-004 Lineberger Comprehensive Cancer Center,CB7295,Chapel Hill,NC 27599,USA [2]Duke University,Department of Surgery,Durham,NC 27710,USA

出　　处：《Protein & Cell》2013年第1期17-26,共10页蛋白质与细胞（英文版）

摘　　要：Plexins and semaphorins are a large family of proteins that are involved in cell movement and response.The importance of plexins and semaphorins has been emphasized by their discovery in many organ systems including the nervous(Nkyimbeng-Takwi and Chapoval,2011;McCormick and Leipzig,2012;Yaron and Sprinzak,2012),epithelial(Miao et al.,1999;Fujii et al.,2002),and immune systems(Takamatsu and Kumanogoh,2012)as well as diverse cell processes including angiogenesis(Serini et al.,2009;Sakurai et al.,2012),embryogenesis(Perala et al.,2012),and cancer(Potiron et al.,2009;Micucci et al.,2010).Plexins and semaphorins are transmembrane proteins that share a conserved extracellular semaphorin do-main(Hota and Buck,2012).The plexins and sema-phorins are divided into four and eight subfamilies respectively based on their structural homology.Semaphorins are relatively small proteins containing the extracellular semaphorin domain and short intra-cellular tails.Plexins contain the semaphorin domain and long intracellular tails(Hota and Buck,2012).The majority of plexin and semaphorin research has fo-cused on the nervous system,particularly the devel-oping nervous system,where these proteins are found to mediate many common neuronal cell processes including cell movement,cytoskeletal rearrangement,and signal transduction(Choi et al.,2008;Takamatsu et al.,2010).Their roles in the immune system are the focus of this review.

关 键 词：PLEXIN SEMAPHORIN immune system den-dritic cell B cell T cell 

分 类 号：R73[医药卫生—肿瘤]