A genetically encoded sulfotyrosine for VHR function research  

作　　者：Yueting Zheng Xiaoxuan Lv Jiangyun Wang 

机构地区：[1]Laboratory of Non-coding RNA,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Protein & Cell》2013年第10期731-734,共4页蛋白质与细胞（英文版）

基　　金：We gratefully acknowledge the National Ba-sic Research Program(973 Program)(Nos.2010CB912301 and 2009CB825505).

摘　　要：Dear Editor,Protein tyrosine phosphorylation is one of the most prevalent forms of post-translational modification and plays a signifi cant role in the control of a variety of cellular processes,including signal transduction,and is implicated in many human diseases(Eckhart et al.,1979;Karisch et al.,2011).The human vac-cinia H1-related phosphatase(VHR),the fi rst human dual specifi city protein phos-phatase(DSP),hydrolyzes phosphate monoesters from phosphotyrosine,phosphothreonine,or phosphoserine residues(Aroca et al.,1995).DSPs func-tion in signal transduction and in control of the cell cycle;more than 20 mamma-lian DSPs have so far been identifi ed.Although VHR can dephosphorylate both Erk and Jnk in vivo(Schumacher et al.,2002),it differs from other‘typi-cal’mitogen activated protein(MAP)kinase phosphatases(MKPs).With only 185 amino acids,VHR consists of only a catalytic domain with no recogniz-ing or docking domain.

关 键 词：al. DISEASES ed. 

分 类 号：R73[医药卫生—肿瘤]