Egg white as a natural and safe biomaterial for enhanced cancer therapy  

作　　者：Jun Huang Xinru You Peikun Xin Zhipeng Gu Chun Chen Jun Wu 

机构地区：[1]Department of Pediatrics.The Seventh Affiliated Hospital of Sun Yat-sen University,Shenzhen 518107,China [2]School of Biomedical Engineering,Sun Yat-sen University,Guangzhou 510006,China [3]College of Polymer Science and Engineering,Sichuan University,Chengdu 610065,China

出　　处：《Chinese Chemical Letters》2021年第5期1737-1742,共6页中国化学快报（英文版）

基　　金：supported by National Science and Technology Major Project of the Ministry of Science and Technology of China (No.2018ZX10301402);International Cooperation and Exchange of the National Natural Science Foundation of China (No.51820105004);China Postdoctoral Science Foundation (No. 2019M663246);the Fundamental Research Funds for the Central Universities (Nos.191gzd35 and 20ykpy15);Guangdong Basic and Applied Basic Research Foundation (No.2019A1515110686);the Seventh Affiliated Hospital of Sun Yat-sen University (Shenzhen) Research Startup Fund (No.ZSQYRSFPD0015);Science and Technology Program of Guangzhou (Nos.201707010094 and 201704020095);Guangdong Innovative and Entrepreneurial Research Team Program (Nos.2016ZT06S252 and 2016ZT06S029);Science and Technology Planning Project of Shenzhen (No.JCYJ20170307141438157);Shenzhen Foundation of Science and Technology (No.JCYJ20170818103626421);National Natural Science Foundation of China (No.51973243)

摘　　要：The last few decades have witnessed the eme rgence of a very large variety of engineered nanomaterials.However,it is far from to meet the growing clinical demand.Actually,nature itself is an excellent na notechnologist,and provides us with a range of wonderful materials,from inorganic particles found in non-life bodies to biofilms,like platelets,erythrocyte membranes,produced by many bacteria or cells.These nanomaterials are entirely natural,and not surprisingly,there is a growing interest in the development of natural nanoproducts.Native components-inspired biomaterials have gained considerable attention owing to their sa fety and functions.In this study,egg white was developed as drug carrier to load PTX by a green and simple one-pot method,and systematic characterization was completed.The results indicated that PTX@EW NPs possess excellent biocompatibility,enhanced tumor targeting capability,effectively reducing the toxic side effects of PTX.The obviously enhanced antitumor effect further confirmed EW was a highly prospective biomaterial in the nano-carrier industry.

关 键 词：Egg white Natural biomaterial NANOCARRIER Biosafe ANTITUMOR 

分 类 号：TQ460.4[化学工程—制药化工]