SorCS2 neurofibrillary tangles-like lesions in AD human cerebrum  

作　　者：Hu Dandan Li Yanan Tu Tian Jiang Juan Yan Xiaoxin Pan Aihua 

机构地区：[1]Department of Anatomy and Neurobiology,Central South University Xiangya School of Medicine,Changsha 410013

出　　处：《解剖学杂志》2021年第S01期71-72,共2页Chinese Journal of Anatomy

摘　　要：Recent findings have indicated that SorCS2,a member of the vacuolar protein sorting 10 protein(VPS10P)family,has relevance to bipolar disorder,schizophrenia,and Alzheimer's disease(AD).We observed SorCS2 can accumulate as neurofibrillary tangles(NFTs)-like lesions in AD human brain cerebrum.Then we set to explore NFTs-like lesions from SorCS2 in aged and AD human cerebrum,and whether this pathological hallmark is unique to AD human brains.We characterized SorCS2 changes in postmortem human brains(n=10)from aged and AD subjects.

关 键 词：LESIONS CS2 ALZHEIMER 

分 类 号：R73[医药卫生—肿瘤]