Inhibition of NLRP3 inflammasomes reduced blood brain barrier damage by DHA during early acute cerebralischemia  

作　　者：Xinli Wang E Lu Jian Li Meng Pang Yanqiang Wang 

机构地区：[1]Weifang Medical University,Weifang 261031,China [2]Department of Neurology II,The Affiliated Hospital of Weifang Medical University

出　　处：《解剖学杂志》2021年第S01期133-133,共1页Chinese Journal of Anatomy

摘　　要：The aim of this study was to explore the neuroprotective effect and mechanism of DHA on cerebral ischemia injury and blood-brain barrier(BBB)disruption.the focal cerebral I/R model was established by middle cerebral artery oclusion(MCAO).BBB permeability was assessed with the leaking amount of Evans Blue and the expression of occludin and ZO-1.The expression of pyrin domain containing(NLRP3)was checked to explore the inhibition of inflammation by DHA.The results showed that DHA could significantly reduce cortical and sub-cortical infarct volumes,neurologic de ficit scores,cerebral edema,BBB permeability after I/R injury.Leaking amount of Evans Blue was reduced by DHA,and occludin and ZO-1 were up-regulated by DHA.The expression of NLRP3 was inhibited after exposure of DHA.Our results indicated that DHA could effectively penetrate the brain of MCAO rats,aleviated the I/R injury by inhibiting NLRP3 inflammasomes and improve BBB disruption,showing a great clinical potential for stroke.

关 键 词：CEREBRAL ISCHEMIA DAMAGE barrier 

分 类 号：R74[医药卫生—神经病学与精神病学]