Characterization of serum estradiol level and tissue estrogen receptor immunostaining with clinical response reproductive factor changes in Chinese female patients with esophageal squamous cell carcinoma  

作　　者：Zhang Dongyun Wu Hongfang Liang Gruina Wei Yan 

机构地区：[1]Department of Pathology,Nanyang Medical College,Nanyang 473061

出　　处：《解剖学杂志》2021年第S01期192-193,共2页Chinese Journal of Anatomy

摘　　要：The prognostic value of estrogen and/or ER on female pa tients with esophageal squamous cell carcinoma(ESCC)is rarely reported.Current study was undertaken to elucidate the associations of serum estradiol level,tissue estrogen receptor alpha(ERa)and estrogen receptor beta(ERβ)expression with clinical response and reproductive factor changes in 387 female ESCC patients.A genome-wide association study on 3921 ESCC patients using 40 SNPs(P≤1×10^(-7))demonstrated that rsl SNP with AA,GG or GA genotype was significantly difference(X^(2)=12.258,8.399,6.671;P=0.002,0.015,0.036)on overall survival.

关 键 词：ESOPHAGEAL patients ESTROGEN 

分 类 号：R73[医药卫生—肿瘤]