Interactions between life expectancy and the incidence and mortality rates of cancer in China: a population-based cluster analysis  

作　　者：Xiuying Gu Rongshou Zheng Changfa Xia Hongmei Zeng Siwei Zhang Xiaonong Zou Zhixun Yang He Li Wanqing Chen 

机构地区：[1]Cancer Research Institute,Cancer Hospital,Xinjiang Medical University,Urumqi 830011,P.R.China [2]National Office for Cancer Prevention and Control,National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,P.R.China

出　　处：《Cancer Communications》2018年第1期459-473,共15页癌症通讯（英文）

基　　金：supported by CAMS Innovation Fund for Medical Sciences(2016-12M-2-004);Ministry of Science and Technology of China(2014FY121100).

摘　　要：Background:The relationship between cancer and life expectancy is well established in both developed and developing countries.China is a vast country with significant geographical differences in population structure and healthcare,and thus provides a unique opportunity to analyze the complex relationship between life expectancy and cancer incidence and mortality rates.Methods:Cancer data were extracted for a total of 255 units(cities or counties)from the 2013 National Central Cancer Registry.Life expectancy data at the unit level were obtained from the National Centers for Disease Control and Prevention.Linear regression analysis was used to analyze the relationship between life expectancy and crude incidence and mortality rates of cancer.In a separate analysis,life expectancy was rated as low(<76.0 years),middle(76-80 years),or high(>80 years).Results:Overall,the cancer incidence and mortality rates positively correlated with life expectancy in both sexes(R at 0.37 and 0.50,P<0.001).The correlation was significant for the following cancers:lung,colorectal,prostate,blad-der and pancreas,as well as for lymphoma in men(R 0.36-0.58,P<0.001),lung,breast,colorectal,thyroid,uterus,and ovary in women(R 0.18-0.51,P<0.001).We failed to observe an association between upper gastrointestinal cancer and life expectancy.The number of cities/counties with low,middle and high life expectancy levels were 110,101 and 44,respectively.The highest age-standardized cancer incidence rate was observed in areas with a high life expec-tancy level(192.83/100,000).The highest age-standardized mortality rate was in areas with the lowest life expectancy(118.44/100,000).Cancers of the stomach,liver and esophagus are major cancer types in areas with low and middle life expectancy.In contrast,areas with high life expectancy had high incidence and mortality rates of colorectal can-cer,breast cancer in women and prostate cancer in men.Conclusions:Longer life expectancy is associated with higher overall cancer incidence and mortality in China.The c

关 键 词：CANCER INCIDENCE MORTALITY Life expectancy China 

分 类 号：R73[医药卫生—肿瘤]