Recent Progress in Non-motor Features of Parkinson’s Disease with a Focus on Circadian Rhythm Dysregulation  

作　　者：Yufei Liu Long Niu Xinyao Liu Cheng Cheng Weidong Le 

机构地区：[1]Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases,the First Affiliated Hospital,Dalian Medical University,Dalian 116021,China [2]Liaoning Provincial Center for Clinical Research on Neurological Diseases,the First Affiliated Hospital,Dalian Medical University,Dalian 116021,China [3]Institute of Neurology,Sichuan Academy of Medical Science-Sichuan Provincial Hospital,University of Electronic Science and Technology of China,Chengdu 610072,China

出　　处：《Neuroscience Bulletin》2021年第7期1010-1024,共15页神经科学通报（英文版）

基　　金：the National Nature Science Foundation of China(81771521);Key Research and Development Plan of Liaoning Science and Technology Department(2018225051);Guangdong Provincial Key R&D Program(2018B030337001);the National Key Research and Development Program of China(2016YFC1306600).

摘　　要：Parkinson’s disease(PD)is the second most common neurodegenerative disease,which manifests with both motor and non-motor symptoms.Circadian rhythm dysregulation,as one of the most challenging non-motor features of PD,usually appears long before obvious motor symptoms.Moreover,the dysregulated circadian rhythm has recently been reported to play pivotal roles in PD pathogenesis,and it has emerged as a hot topic in PD research.In this review,we briefly introduce the circadian rhythm and circadian rhythm-related genes,and then summarize recent research progress on the altered circadian rhythm in PD,ranging from clinical features to the possible causes of PD-related circadian disorders.We believe that future comprehensive studies on the topic may not only help us to explore the mechanisms of PD,but also shed light on the better management of PD.

关 键 词：Circadian rhythm dysregulation Circadian rhythm gene Parkinson’s disease REM sleep behavior disorder DOPAMINE 

分 类 号：R74[医药卫生—神经病学与精神病学]