Molecular mechanism for the involvement of nuclear receptor FXR in HBV-associated hepatocellular carcinoma  

作　　者：Yong-dong Niu Wen Xie Wen-xin Qin 

机构地区：[1]State Key Laboratory of Oncogenes and Related Genes,Shanghai Cancer Institute,Shanghai Jiao Tong University School of Medicine,Shanghai 200032,China [2]Center for Pharmacogenetics,Department of Pharmaceutical Sciences,University of Pittsburgh,Pittsburgh,PA 15261,USA

出　　处：《Acta Pharmaceutica Sinica B》2011年第2期73-79,共7页药学学报（英文版）

基　　金：This work was supported by the National Key Basic Research Program of China(2009CB521803);the National Natural Science Foundation of China(30973492);the National Key Sci-Tech Special Project of China(2008ZX10002-019);the Projects of the State Key Laboratory of Oncogenes and Related Genes(80-08-02,91-09-01);And Yongdong Niu is supported by Visiting Scholarship from the Shanghai Jiao Tong University(2009-2010)and Shanghai Jiao Tong University School of Medicine(2009-2010).

摘　　要：Farnesoid X receptor(FXR,also termed nuclear receptor NR1H4)is critically involved in the regulation of nascent bile formation and bile acid enterohepatic circulation.FXR and bile acids have been shown to play roles in liver regeneration and inflammatory responses.There is increasing evidence suggesting that FXR and the FXR signaling pathway are involved in the pathophysiology of a wide range of liver diseases,such as viral hepatitis,cirrhosis,and hepatocellular carcinoma(HCC).Here we discuss the latest discoveries of FXR functions with relevance to bile acid metabolism and HBVassociated HCC.More specifically,the goal of this review is to discuss the roles of FXR and bile acids in regulating HBV replication and how disregulation of the FXR-bile acid signaling pathway is involved in HBV-associated hepatocarcinogenesis.

关 键 词：Farnesoid X receptor Hepatitis B virus Bile acids INFLAMMATION Hepatocellular carcinoma 

分 类 号：R57[医药卫生—消化系统]