Anti-tumor targeted drug delivery systems mediated by aminopeptidase N/CD13  

作　　者：Xun Wang Bin Wang Qiang Zhang 

机构地区：[1]School of Pharmaceutical Sciences,Peking University,Beijing 100191,China [2]Department of Endocrinology,Guang’an men Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China

出　　处：《Acta Pharmaceutica Sinica B》2011年第2期80-83,共4页药学学报（英文版）

基　　金：This research was supported by the National Basic Research Program of China(No.2009CB930300);State Key Projects(No.2009ZX09310-001);the 863 Project(No.2007AA021811).

摘　　要：Aminopeptidase N(APN)/CD13 is a transmembrane glycoprotein,which is overexpressed on tumor neovascular endothelial cells and most tumor cells,where it plays an important role in tumor angiogenesis.Peptides containing the Asn-Gly-Arg(NGR)motif can specifically recognize APN/CD13 allowing them to act as tumor-homing peptides for the targeted delivery of anti-tumor drugs to tumor neovascular endothelial cells and tumor cells.This article reviews the literature and recent developments related to APN/CD13,its role in tumor growth and some antitumor drug delivery systems containing NGR peptides designed to target APN/CD13.

关 键 词：Aminopeptidase N/CD13 NGR peptides ANTI-TUMOR Targeted drug delivery system 

分 类 号：R73[医药卫生—肿瘤]