Phosphinic Acid/Nal Mediated Reductive Cyclization Approach for Accessing the L-1-Deoxynojirimycin Using a Two-Component Three-Centered (2C3C) Ugi Type Reaction  

作　　者：Chandra S Azad Pratibha Shukla Mark A Olson Anudeep K Narula 

机构地区：[1]Institute for Molecular Design and Synthesis,School of Pharmaceutical Science&Technology,Health Science Platform,Tianjin University,92 Weijin Road,Nankai District,Tianjin 300072,China [2]"Hygeia",Centre of Excellence in Pharmaceutical Sciences,Guru Gobind Singh Indraprostho University,Sector 16-C,Dwarka,New Delhi 110078,India [3]Department of Chemistry,Northwestern University,2145 Sheridan Rood,Evanston,IL 60208,USA

出　　处：《Chinese Journal of Chemistry》2021年第6期1503-1510,共8页中国化学（英文版）

摘　　要：A catalytic two-component three-centered(2C3C)Ugi-type reaction was developed for the synthesis of L-1-deoxynojirimycin(DNJ)isomers using a chiron approach.This new and quite mild catalytic system,comprised of phenylphosphinic acid/Nal,was used to synthesize both the L-allo-DNJ and L-altro-DNJ in high yield.

关 键 词：AZASUGARS Multicomponent reactions Nitrilium ion ISOCYANIDE Reductive cyclization 

分 类 号：O62[理学—有机化学]