Diabetes mellitus and Parkinson's disease:dangerous liaisons between insulin and dopamine  

作　　者：Angela De Iuliis Ennio Montinaro Giuseppe Fatati Mario Plebani Carlo Colosimo 

机构地区：[1]Department of Medicine-DiMED,University of Padova,Italy [2]Department of Neurology,Santa Maria University Hospital,Terni,Italy [3]Italian Obesity Network,Terni,Italy [4]Department of Medicine-DiMED,University of Padova,Padova,Italy/Department of Laboratory Medicine-Hospital of Padova,Padova,Italy

出　　处：《Neural Regeneration Research》2022年第3期523-533,共11页中国神经再生研究（英文版）

摘　　要：The relationship between diabetes mellitus and Parkinson's disease has been described in several epidemiological studies over the 1960 s to date.Molecular studies have shown the possible functional link between insulin and dopamine,as there is strong evidence demonstrating the action of dopamine in pancreatic islets,as well as the insulin effects on feeding and cognition through central nervous system mechanism,largely independent of glucose utilization.Therapies used for the treatment of type 2 diabetes mellitus appear to be promising candidates for symptomatic and/or disease-modifying action in neurodegenerative diseases including Parkinson's disease,while an old dopamine agonist,bromocriptine,has been repositioned for the type 2 diabetes mellitus treatment.This review will aim at reappraising the different studies that have highlighted the dangerous liaisons between diabetes mellitus and Parkinson's disease.

关 键 词：DOPAMINE GLP-1 INSULIN Parkinson's disease type 2 diabetes mellitus 

分 类 号：R587.1[医药卫生—内分泌] R742.5[医药卫生—内科学]