宫颈上皮内瘤变和宫颈癌患者的阴道微生态特点  

Analysis of Vaginal Microecological in Women with Cervical Intraepithelial Neoplasia and Cervical Cancer

作　　者：谭丁及 尹洪莉 朱锐 张曦 余鑫 飞勇[3] 李昕[1] 段铭 何亮[1] 杨宏英[1] TAN Ding-ji;YIN Hong-li;ZHU Rui;ZHANG Xi;YU Xin;FEI Yong;LI Xin;DUAN Ming;HE Liang;YANG Hong-ying(Dept.of Laboratory,The 3rd Affiliated Hospital of Kunming Medical University/Cancer Hospital of Yunnan/Cancer Center of Yunnan,Kunming Yunnan 650118,China;Dept.of Gynecology,The 3rd Affiliated Hospital of Kunming Medical University/Cancer Hospital of Yunnan/Cancer Center of Yunnan,Kunming Yunnan 650118,China;Dept.of Radiology,The 3rd Affiliated Hospital of Kunming Medical University/Cancer Hospital of Yunnan/Cancer Center of Yunnan,Kunming Yunnan 650118,China)

机构地区：[1]昆明医科大学第三附属医院/云南省肿瘤医院/云南省癌症中心检验科,云南昆明650118 [2]昆明医科大学第三附属医院/云南省肿瘤医院/云南省癌症中心妇科,云南昆明650118 [3]昆明医科大学第三附属医院/云南省肿瘤医院/云南省癌症中心放射科,云南昆明650118

出　　处：《昆明医科大学学报》2021年第8期118-122,共5页Journal of Kunming Medical University

基　　金：国家癌症中心及中国癌症基金会基金资助项目(NCC2017A34,NCC2017A33);云南省科技厅-昆明医科大学联合专项基金资助项目[2018FE001(-248)];云南省科技厅基础研究专项基金资助项目(202001AS070033);云南省卫生科技计划基金资助项目(2018NS0062);云南省教育厅科学研究基金资助项目(2020J0196);昆明医科大学研究生创新基金资助项目(2021S069)。

摘　　要：目的研究宫颈上皮内瘤变和宫颈癌患者阴道微生态特点,为宫颈疾病预防和治疗提供参考。方法选取昆明医科大学第三附属医院(云南省肿瘤医院)2018年7月至2018年10月病理诊断为宫颈上皮内瘤变患者(n=65)、宫颈癌患者(n=51)和同期体检健康女性(n=88)为研究对象,收集阴道拭子,通过显微镜镜检进行微生态评价。结果与健康组相比,宫颈上皮内瘤变组在菌群密集度构成上,差异有统计学意义(P<0.05),在菌群多样性、优势菌、pH、Nugent评分构成上,差异无统计学意义(P>0.05)。宫颈癌组与健康组在菌群密集度、优势菌、pH、Nugent评分构成上,差异均有统计学意义(P<0.05),在菌群多样性构成上,差异无统计学意义(P>0.05)。结论宫颈上皮内瘤变和宫颈癌患者阴道微生态失调,以宫颈癌失调最为显著。尽早发现阴道微生态失调,恢复阴道微生态平衡,有利于防治宫颈癌。Objective To investigate the characteristics of vaginal microecology in patients with cervical intraepithelial neoplasia and cervical cancer,and provide information for the prevention and treatment of cervical diseases.Methods From July 2018 to October 2018,patients with cervical intraepithelial neoplasia(n=65),patients with cervical cancer(n=51)and healthy control(n=88)in Yunnan Cancer Hospital were selected.Vaginal swabs were collected and microecological assessment were performed by microscopic examination.Results Compared with healthy group,there was a significant difference in the composition of bacterial density in the cervical intraepithelial neoplasia group(P<0.05),despite there was no significant difference in flora diversity,dominant bacteria,pH and Nugent score(P>0.05).There were significant differences in flora density,dominant bacteria,pH and Nugent score composition between the cervical cancer group and the healthy group(P<0.05)and there was no significance in the composition of bacterial diversity(P>0.05).Conclusion Patients with cervical intraepithelial neoplasia and cervical cancer have microecological imbalance,especially in cervical cancer patients.Early detection and restoration of female vaginal microecological imbalance are beneficial for the prevention and treatment of cervical cancer.

关 键 词：阴道微生态 宫颈癌 宫颈上皮内瘤变 乳杆菌 

分 类 号：R737.33[医药卫生—肿瘤]