传染病流行病学中基本再生数与有效再生数指标的研究进展  

Research progress on the basic and effective reproductive number in the epidemiology of infectious diseases

作　　者：张晓宝 严丹莹 陈灿 蒋黛西 丁丞[1] 蓝蕾 吴杰[1] 杨仕贵[1] ZHANG Xiao-bao;YAN Dan-ying;CHEN Can;JIANG Dai-xi;DING Cheng;LAN Lei;WU Jie;YANG Shi-gui(The First Affiliated Hospital,College of Medicine,Zhejiang University,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases of Zhejiang University,National Clinical Research Center for Infectious Diseases of Zhejiang University,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属第一医院,浙江大学传染病诊治国家重点实验室,感染性疾病诊治协同创新中心,浙江大学国家感染性疾病临床医学研究中心,杭州310003

出　　处：《中华疾病控制杂志》2021年第7期753-757,790,共6页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81672005,U1611264);国家科技重大专项(2018ZX10715-014-002);科技部中青年科技创新领军人才(2017RA2120)。

摘　　要：当一种新的传染病出现时,研究者们往往会用一些流行病学指标来衡量它的传播能力,其中一类重要的指标就是基本再生数(R0)和有效再生数(Re)。然而,R0和Re的定义、计算方法和结果解释等在许多场景中被错误地理解,甚至误用。本文围绕R0和Re的定义、计算方法、两者关系、影响因素、流行病学意义、应用注意事项以及常见传染病的基本再生数等进行综述,为卫生决策部门利用R0和Re制定针对性疫情防控措施提供参考。With the occurrence of an emerging infectious disease,some epidemiological indicators are used to measure the transmission of the disease.Basic reproduction number(R0)and effective reproduction number(Re)are two crucial indicators among them.However,the definition,calculation,and interpretation of R0 and Re are misunderstood or even misused in many cases.This review introduces the definition,calculation,influence factors,epidemiology significance,notes for application,and the R0 of some common infectious diseases,aiming to provide scientific guidance for health decision-making departments to prevent and control the epidemic of infectious disease.

关 键 词：传染病流行病学 基本再生数 有效再生数 

分 类 号：R181[医药卫生—流行病学]