Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome  

作　　者：Ziying Zhang Haosheng Tang Peng Chen Hui Xie Yongguang Tao 

机构地区：[1]Key Laboratory of Carcinogenesis and Cancer Invasion,Ministry of Education,Department of Pathology,Xiangya Hospital,Central South University,410078 Hunan,China [2]NHC Key Laboratory of Carcinogenesis(Central South University),Cancer Research Institute and School of Basic Medicine,Central South University,410078 Changsha,Hunan,China [3]Hunan Key Laboratory of Tumor Models and Individualized Medicine,Department of Thoracic Surgery,Second Xiangya Hospital,Central South University,410011 Changsha,China [4]Department of Oncology,Third Xiangya Hospital,Central South University,410013 Changsha,China [5]Department of Urology,Xiangya Hospital,Central South University,410008 Changsha,China [6]Department of Thoracic and Cardiovascular Surgery,Second Xiangya Hospital of Central South University,410011 Changsha,China

出　　处：《Signal Transduction and Targeted Therapy》2019年第1期264-297,共34页信号转导与靶向治疗（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(81672787[Y.T.]);the National Basic Research Program of China(2015CB553903[Y.T.]);an the Overseas Expertise Introduction Project for Discipline Innovation(111 Project,No.111-2-12).

摘　　要：The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects of host pathophysiology.Remarkable progress in large-scale sequencing and mass spectrometry has increased our understanding of the influence of the microbiome and/or its metabolites on the onset and progression of extraintestinal cancers and the efficacy of cancer immunotherapy.Given the plasticity in microbial composition and function,microbial-based therapeutic interventions,including dietary modulation,prebiotics,and probiotics,as well as fecal microbial transplantation,potentially permit the development of novel strategies for cancer therapy to improve clinical outcomes.Herein,we summarize the latest evidence on the involvement of the gut microbiome in host immunity and metabolism,the effects of the microbiome on extraintestinal cancers and the immune response,and strategies to modulate the gut microbiome,and we discuss ongoing studies and future areas of research that deserve focused research efforts.

关 键 词：METABOLISM IMMUNITY MANIPULATION 

分 类 号：R73[医药卫生—肿瘤]