Mammary stem cells:angels or demons in mammary gland?  

作　　者：Xueman Chen Qiang Liu Erwei Song 

机构地区：[1]Breast Tumor Center,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou,China [2]Guangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation,Medical Research Center,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou,China

出　　处：《Signal Transduction and Targeted Therapy》2017年第1期312-319,共8页信号转导与靶向治疗（英文）

基　　金：This work was supported by grants from the Natural Science Foundation of China(81472468,81490750,81230060,81442009,81472467,81272894,81372819);Science Foundation of Guangdong Province(2016A030306023,2014A030313094,S2012030006287,2014A030313175);973(SQ2015CB050449)Projects from Ministry of Science and Technology of China.

摘　　要：A highly dynamic development process exits within the epithelia of mammary gland,featuring morphogenetic variation during puberty,pregnancy,lactation,and regression.The identification of mammary stem cells(MaSCs)via lineage-tracing studies has substantiated a hierarchical organization of the mammary epithelia.A single MaSC is capable of reconstituting the entirely functional mammary gland upon orthotopic transplantation.Although different mammary cell subpopulations can be candidate cells-of-origin for distinct breast tumor subtypes,it still lacks experimental proofs whether MaSCs,the most primitive cells,are the‘seeds’of malignant transformation during most,if not all,tumorigenesis in the breast.Here,we review current knowledge of mammary epithelial hierarchy,highlighting the roles of mammary stem/progenitor cells and breast cancer stem cells(BCSCs)along with their key molecular regulators in organ development and cancer evolution.Clarifying these issues will pave the way for developing novel interventions toward stem/progenitor cells in either prevention or treatment of breast cancer(BrCa).

关 键 词：PREVENTION BREAST entirely 

分 类 号：R73[医药卫生—肿瘤]