Neurons generated from carcinoma stem cells support cancerprogression  

作　　者：Ran Lu Chuanwen Fan Wenqi Shangguan Yuan Liu Yu Li Yanna Shang Dongqin Yin Shengliang Zhang Qiaorong Huang Xue Li Wentong Meng Hong Xu Zongguang Zhou Jiankun Hu Weimin Li Lunxu Liu Xianming Mo 

机构地区：[1]Laboratory of Stem Cell Biology,State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy,West China Hospital,Sichuan University,Chengdu,China [2]Institute of Digestive Surgery,State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy,West China Hospital,Sichuan University,Chengdu,China [3]Department of Gastrointestinal Surgery,State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy,West China Hospital,Sichuan University,Chengdu,China [4]Laboratory of Gastric Cancer,State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy,West China Hospital,Sichuan University,Chengdu,China [5]Department of Respiratory and Critical Care Medicine,State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy,West China Hospital,Sichuan University,Chengdu,China [6]Department of Thoracic Surgery,State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy,West China hospital,Sichuan University,Chengdu,China.

出　　处：《Signal Transduction and Targeted Therapy》2017年第1期320-329,共10页信号转导与靶向治疗（英文）

基　　金：This work was supported by the National Basic Research Program of China(to XM 2015CB942800);the Nature Science Foundation of China(to XM 81361120381;to CF 81402446).

摘　　要：Recent evidences show that nervous system acts as a crucial part of cancer microenvironment.Infiltration of nerve fibers into cancer microenvironment has an important active role in cancer progression.The stimulations of both cancer growth and metastasis by members of nervous system such as neurons and glial cells have been demonstrated.However,how the nervous system is built in cancer is largely unknown.Here we show that a fraction of cancer stem cells(CSCs)derived from patients with gastric carcinoma and colorectal carcinoma are capable of producing neurons that are involved in tumor neurogenesis and tumor growth.Cancer stem cell monoclone derived from a single cancer stem cell was able to generate neurons including sympathetic and parasympathetic neurons to take part in the nervous system in cancer tissues.Knocking down the neural cell generating capability of the human CSCs inhibited the growth of xenograft tumors in mouse model.Our data demonstrate that human CSCs are able to produce one of most important components in the cancer microenvironment that are required for cancer development and progression.

关 键 词：CANCER inhibited STIMULATION 

分 类 号：R73[医药卫生—肿瘤]