Taxifolin attenuates ischemia-reperfusion induced oxidative ovarian damage in rats  

作　　者：Sevil Kiremitli Tunay Kiremitli Umit Nayki Nesrin Yilmaz Can Turkler Kemal Dinc Renad Mammadov Gulce Naz Yazici Mine Gulaboglu Nihal Cetin 

机构地区：[1]Erzincan Binali Yildirim University Faculty of Medicine,Department of Obstetrics and Gynaecology,Erzincan,Turkey [2]Erzincan Binali Yildirim University Faculty of Medicine,Department of Pharmacology,Erzincan,Turkey [3]Erzincan Binali Yildirim University Faculty of Medicine,Department of Histology and Embryology,Erzincan,Turkey [4]Ataturk University Faculty of Pharmacy,Department of Biochemistry,Erzurum,Turkey [5]Selcuk University Faculty of Medicine,Department of Pharmacology,Konya,Turkey

出　　处：《Asian pacific Journal of Reproduction》2021年第4期168-175,共8页亚太生殖杂志（英文版）

摘　　要：Objective:To investigate preventive effects of taxifolin on ischemia-reperfusion induced oxidative ovarian damage in rats.Methods:A total of 18 female Wistar albino rats were randomly and equally divided into three groups:the sham group,the ovarian ischemia reperfusion group,and the 50 mg/kg taxifolin+ovarian ischemia reperfusion group.The ovarian ischemia reperfusion and taxifolin+ovarian ischemia reperfusion groups were exposed to ischemia for 2 h and then followed by two-hour reperfusion protocol.Biochemical and histopathologic examinations were performed on the extracted ovaries.Results:Levels of malondialdehyde and cyclooxygenase-2 were increased,while reduced-glutathione and cyclooxygenase-1 were decreased in the ovarian ischemia reperfusion group.However,these values were reversed in the taxifolin+ovarian ischemia reperfusion group.Similarly,the number of primordial and developing follicules decreased in the ovarian ischemia reperfusion group,while they were within normal range in the taxifolin+ovarian ischemia reperfusion group.Conclusions:Ischemia followed by reperfusion leads to oxidative stress-related ovarian injury,and taxifolin may be useful for protecting ovarian tissue from such injury.

关 键 词：ANTIOXIDANTS ISCHEMIA-REPERFUSION Ovarian damage RAT TAXIFOLIN Oxidative stress Ovarian torsion 

分 类 号：R74[医药卫生—神经病学与精神病学]