Research progress of strontium in promoting periodontal tissue regeneration  

作　　者：Bai-Jie Ren Xin-Ying Zou Yue Liu Lei Wang Dong-Hui Gao 

机构地区：[1]Department of Endodontics,School and Hospital of Periodontology,Jilin University,Changchun 130021,China

出　　处：《Journal of Hainan Medical University》2021年第15期65-68,共4页海南医学院学报（英文版）

基　　金：ilin Provincial Science and Technology Development Plan Project(No.20190303183SF);the Undergraduate Teaching Reform Research Project of Jilin University(No.2019XYB318);Natural Science Foundation of Jilin Province(Discipline Layout Project)(No.20200201389JC)。

摘　　要：Periodontal disease is a chronic infectious disease of the oral cavity.Its main clinical features are periodontal pocket formation and alveolar bone resorption.Scholars'research hotspot is to achieve periodontal tissue regeneration in patients.Studies have found that strontium has certain potential in promoting periodontal tissue regeneration.In recent years,scholars have been conducting research on strontium and periodontal tissue regeneration,with a view to opening a new path for periodontal disease treatment.This article reviews the research status of strontium and periodontal tissue regeneration.The review results show that strontium can induce the proliferation and differentiation of PDLSCs and promote the regeneration of lost bone tissue;it can inhibit osteoclast activity and induce osteoclast apoptosis through a variety of signaling pathways,thereby inhibiting bone resorption;Promote bone formation;Strontium also has the function of promoting early angiogenesis and suppressing immune inflammatory response.Because the current research on strontium and periodontal tissue regeneration is only focused on in vivo and in vitro experiments,there is no relevant clinical trial to apply strontium to periodontal tissue regeneration.Therefore,if strontium is used to promote periodontal tissue regeneration to achieve the treatment of periodontal disease,further research is needed.

关 键 词：Periodontal tissue regeneration STRONTIUM OSTEOBLAST Periodontal ligament stem cells 

分 类 号：R78[医药卫生—口腔医学]