Effect of Cisplatin on the Flexibility of Linear DNA  

作　　者：JI Chao ZHANG Ling-Yun HOU Xi-Miao DOU Shuo-Xing WANG Peng-Ye 季超;张凌云;侯锡苗;窦硕星;王鹏业(Key Laboratory of Soft Matter Physics,Beijing National Laboratory for Condensed Matter Physics,Institute of Physics,Chinese Academy of Sciences,Beijing 100190)

机构地区：[1]Key Laboratory of Soft Matter Physics,Beijing National Laboratory for Condensed Matter Physics,Institute of Physics,Chinese Academy of Sciences,Beijing 100190

出　　处：《Chinese Physics Letters》2011年第6期344-347,共4页中国物理快报（英文版）

基　　金：by the National Natural Science Foundation of China under Grant No 10834014;the National Basic Research Program of China under Grant No 2009CB930704。

摘　　要：With the aid of an atomic force microscope(AFM),we study the interaction between linear DNA fragment and cisplatin.For different cisplatin concentrations,the AFM used to observe the conformation of DNA has a gradual change.The contour length,the end-to-end distance and the local bend angles of the linear DNA fragment can be accurately measured.The persistence length of DNA interacting with cisplatin is decreased with the increasing cisplatin concentration.Furthermore,it is demonstrated that the local bend angles of DNA chains are increased by the binding interaction of cisplatin.

关 键 词：CISPLATIN CONCENTRATION CISPLATIN 

分 类 号：R73[医药卫生—肿瘤]