基于肠-肝轴与肝病实脾理论探讨脂肪肝的发病与治疗思路  

Discussion on Pathogenesis and Treatment of Fatty Liver Based on the Enteric-Hepatic Axis and Theory of Strengthening Spleen in Liver Diseases

作　　者：周怡驰 胡世平 晏军[1] 冉云[2] 李玲 ZHOU Yichi;HU Shiping;YAN Jun;RAN Yun;LI Ling

机构地区：[1]北京中医药大学东直门医院,北京100020 [2]北京中医药大学深圳医院,广东深圳518172

出　　处：《新中医》2021年第14期186-189,共4页New Chinese Medicine

基　　金：国家自然科学基金资助项目(81973733);广东省自然科学基金资助项目(2019A1515011555)。

摘　　要：近年现代医学研究表明,肠-肝轴参与脂肪肝的发病机制。胡世平教授将肠-肝轴和中医肝病实脾理论相结合,探讨脂肪肝的中医发病机理与治疗,指出脂肪肝主要责之肝脾同病,以脾虚调节脂代谢失常为本,肠道菌群失衡属脾虚的微观表现,肠-肝轴或为肝脾同病的病理基础;肝病实脾理论指导脂肪肝治疗的核心在于调脾,其机理或通过调节肠-肝轴,促进恢复肠道菌群稳态和肝功能,以延缓、阻止疾病发展。Recent modern medical studies have shown that the enteric-hepatic axis is involved in the pathogenesis of fatty liver.Prof.HU Shiping combined the enteric-hepatic axis with the theory of strengthening the spleen in liver diseases to explore the pathogenesis and treatment of fatty liver in Chinese medicine.It was pointed out that the main cause of fatty liver is the co-occurrence of liver and spleen diseases;fatty liver is originated from the abnormal regulation of lipid metabolism due to spleen deficiency;the imbalance of intestinal flora is the microscopic manifestation of spleen deficiency;and that the enteric-hepatic axis may be the pathological basis of co-occurrence of liver and spleen diseases.The core of the theory of strengthening the spleen in liver diseases to guide the treatment of fatty liver lies in regulating the spleen,which may promote the recovery of intestinal flora homeostasis and liver function by regulating the enteric-hepatic axis,so as to delay and prevent the development of the disease.

关 键 词：脂肪肝 肠道菌群 肠-肝轴 肝病实脾 胡世平 

分 类 号：R228[医药卫生—中医基础理论] R575.5[医药卫生—中医学]