Polymorphism study of nine SNPs associated with subjective response to alcohol in Chinese Han, Hui, Tibetan, Mongolian and Uygur populations  

作　　者：Qingtao Wei Yi Ye Fan Chen Jienan Li Hao Wu Yingqiang Fu Youyi Yan Linchuan Liao 

机构地区：[1]Department of Forensic Toxicological Analysis,West China School of Basic Medical Sciences and Forensic Medicine,Sichuan University,Chengdu,China

出　　处：《Forensic Sciences Research》2018年第2期124-129,共6页法庭科学研究（英文）

基　　金：Ethical approval was given by the medical ethics committee of Sichuan University with the following reference number:2012-001-1.

摘　　要：Heavy alcohol drinking is a major public health problem,causing a large disease,social and economic burden in societies.Subjective response (SR) to alcohol is an intermediate characteristic of heavy drinking.A variety of candidate genes have been reported to be associated with SR to alcohol.In this study,we investigated nine single nucleotide polymorphisms (SNPs) related to SR to alcohol in healthy individuals from five Chinese ethnic groups,the Han,Hui,Tibetan,Mongolian and Uygur populations,and a total of 584 bloodstain samples were collected.The nine SNPs included four SNPs in alcohol-metabolizing genes (ADH1B,ADH1C,ALDH2 and CYP2E1*5B) and five SNPs in genes of neurobiological pathways (GABRA2,OPRM1,CHRNA3,HYKK and SLC6A4).A SNaPshot analysis method was developed to type these SNPs simultaneously,and all samples were typed successfully.Statistical analyses of the allele frequencies indicated that the frequencies of all SNPs,except for ADH1C,showed varying degrees of difference in the five studied ethnic groups.Tibetans showed the highest frequencies of risk alleles for heavy drinking at most loci.The genetic polymorphic differences found in this study revealed the variation in genetic susceptibility to heavy drinking in the studied populations.

关 键 词：Forensic science forensic genetics alcohol drinking heavy drinking subjective response single nucleotide polymorphism POLYMORPHISMS genetic 

分 类 号：R57[医药卫生—消化系统]