C2H2型锌指蛋白在肿瘤基因调控中的研究进展  

Research progress in gene regulation of C2H2 zinc finger protein in tumor

作　　者：韩小暖 陈浩暘[1] 张忠[2] 薄威[2] HAN Xiaonuan;CHEN Haoyang;ZHANG Zhong;BO Wei(The First Delivery Room,Shengjing Hospital Affiliated to China Medical University,Shenyang,Liaoning,110000;Pathological Teaching and Research Office of Shenyang Medical College,Shenyang,Liaoning,110032)

机构地区：[1]中国医科大学附属盛京医院第一分娩室,辽宁沈阳110000 [2]沈阳医学院病理教研室,辽宁沈阳110032

出　　处：《实用临床医药杂志》2021年第13期110-114,共5页Journal of Clinical Medicine in Practice

基　　金：辽宁省科学技术计划项目(20170540885);沈阳医学院青年科学研究基金项目(20202025)。

摘　　要：锌指蛋白是人类基因组中规模最大的转录因子家族,锌指结构的多种组合方式决定其在生物学行为上表现出不同功能。关于不同锌指蛋白在恶性肿瘤癌变过程中的作用机制尚待进一步研究。作者简要阐述了C2H2型锌指蛋白在转录调节和翻译后修饰的作用机制并总结其在不同肿瘤中的调控作用。Zinc finger proteins are the largest family of transcription factors in the human genome.Various combinations of zinc finger structures determine different functions in biological behavior,including regulation of gene expression,cell differentiation and embryonic development at the level of transcription and translation.The mechanism of action of different zinc finger proteins in the malignant process of cancer needs to be further studied.In this article,the mechanism of C2H2 zinc finger protein transcription regulation and post-translational modification was briefly reviewed,and its regulatory roles in different tumors were summarized.

关 键 词：锌指蛋白 C2H2型 转录因子 肿瘤 基因调控 乙酰化 

分 类 号：R730.7[医药卫生—肿瘤] R730.5[医药卫生—临床医学]