Photo-triggered nucleus targeting for cancer drug delivery  

作　　者：Yafei Li Wen Lv Lang Wang Yarning Zhang Lipeng Yang Tianyi Wang Linyong Zhu Yufeng Wang Weiping Wang 

机构地区：[1]Department of Pharmacology and Pharmacy,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong,China [2]Dr.Li Dak-Sum Research Centre,The University of Hong Kong,Hong Kong,China [3]Department of Chemistry,The University of Hong Kong Hong Kong China [4]School of Chemistry and Molecular Engineering East China University of Science and Technology,Shanghai 200030,China

出　　处：《Nano Research》2021年第8期2630-2636,共7页纳米研究（英文版）

基　　金：supported by the Research Grants Council of Hong Kong(Early Career Scheme,No.27115220);Ming Wai Lau Centre for Reparative Medicine Associate Member Program,and Young Scientists Fund of the National Natural Science Foundation of China(No.81803469);We thank Dr.Jenny Lam at The University of Hong Kong for providing the A549 cell line.We acknowledge the assistance of The University of Hong Kong Li Ka Shing Faculty of Medicine Faculty Core Facility.

摘　　要：Here,we report a strategy to deliver drug nanoparticles into cells with nucleus-targeting ability under a spatiotemporal control.The nanoparticles were constructed through self-assembly of photoresponsive prodrugs and free drugs.By incorporating a nucleus localization sequence in the system,drug nanoparticles could be delivered into nuclei upon visible light irradiation.The drug nanoparticles showed high drug loading capacity and specific nucleus-targeting ability,which efficiently killed cancer cells.This self-assembly strategy could be applied to other hydrophobic drugs and targeting ligands for photo-controlled organelle-targeted drug delivery.

关 键 词：phototargeting dePEGylation nucleus targeting COUMARIN photoresponsive prodrugs 

分 类 号：R730[医药卫生—肿瘤]