In vivo Self-assembled Peptide Nanoprobes for Disease Diagnosis  

作　　者：YANG Jia ZHENG Rui AN Hongwei WANG Hao 

机构地区：[1]CAS Center for Excellence in Nanoscience,CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology(NCNST),Beijing,100190,P.R.China [2]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences(UCAS),Beijing,100049,P.R.China [3]School of Future Technology,University of Chinese Academy of Sciences(UCAS),Beijing,100049,P.R.China [4]School of Nanoscience and Technology,University of Chinese Academy of Sciences(UCAS),Beijing,100049,P.R.China

出　　处：《Chemical Research in Chinese Universities》2021年第4期855-869,共15页高等学校化学研究（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.52003270,51725302,11621505);the National Key R&D Program of China(No.2020YFA0210800);the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000);the Key Research Program for Frontier Sciences,Chinese Academy of Sciences(No.ZDBS-LY-SLH039).

摘　　要：In vivo imaging is creating great opportunities for disease diagnosis as a research tool. Probes are usually used to observe physiological structures in vivo clearly. Recent progresses of nanoprobes are important for the generation of high resolution and high contrast images required by accurate and precision disease diagnosis. In vivo self-assembled peptide(SAP) nanoprobes are playing major roles in in vivo imaging by modularity of design, high imaging contrast, response to the location of the lesion, and long-time retention in the lesion. And the response to lesion and long-term retention in there can enhance imaging sensitivity and specificity of in vivo SAP nanoprobes. Therefore, in vivo SAP nanoprobes are simple ancillary contrast entities to optimize the imaging effect. In this review, the recent progress of in vivo SAP nanoprobes for in vivo imaging, from molecular design of peptides to biomedical and clinical applications including disease diagnosis and disease-related molecular imaging is systematically summarized. We evaluate their ability, including sensitivity and specificity to provide relevant information under preoperative and during surgery circumstances and critically their likelihood to be clinically translated. Finally, a brief outlook on remaining challenges and potential directions for future research in this area is presented.

关 键 词：In vivo self-assembly NANOPROBE PEPTIDE Disease diagnosis 

分 类 号：TB383[一般工业技术—材料科学与工程]