DNA methylation profile of a hepatosplenic gamma/delta T-cell lymphoma patient associated with response to interferon-α therapy  

作　　者：Jaydeep Bhat Anke KBergmann Silvio Waschina Christoph Nerl Christoph Kaleta Reiner Siebert Ole Ammerpohl Dieter Kabelitz 

机构地区：[1]Institute of Immunology,Christian-Albrechts-University Kiel&University Hospital Schleswig-Holstein,Campus Kiel,Kiel,Germany [2]Metabolic Programming,School of Life Sciences Weihenstephan,Technical University Munich(TUM),85354,Freising,Germany [3]Institute of Human Genetics,Christian-Albrechts-University Kiel&University Hospital Schleswig-Holstein,Campus Kiel,Kiel,Germany [4]Institute of Human Genetics,Medical School Hannover,Hannover,Germany [5]Institute of Experimental Medicine,Christian-Albrechts-University Kiel&University Hospital Schleswig-Holstein,Campus Kiel,Kiel,Germany [6]Institute of Human Nutrition and Food Science,Christian-Albrechts-University Kiel,Kiel,Germany [7]Städtisches Krankenhaus München-Schwabing,Munich,Germany [8]Institute of Human Genetics,Ulm University&Ulm University Medical Center,89081,Ulm,Germany

出　　处：《Cellular & Molecular Immunology》2021年第5期1332-1335,共4页中国免疫学杂志（英文版）

基　　金：supported by the Deutsche Forschungsgemeinschaft(DFG)through the Cluster of Excellence“Inflammation-at-Interfaces”EXC306-PN and EXC306-PM(D.K.,O.A.and C.K.);the Werner-und-Klara-Kreitz Foundation(JB).

摘　　要：The 2–5%γδT cells in healthy human peripheral blood recognize nonpeptide antigens,in contrast toαβT cells.1 DistinctγδT-cell malignancies have been identified,with hepatosplenic T-cell lymphoma(γδ-HSTL)being a rare but aggressive(median survival 13 months)subset.2γδ-HSTL usually presents with hepatosplenomegaly without lymphadenopathy,anemia,and thrombocytopenia.It is histologically characterized by the involvement of the hepatic sinusoids,splenic red pulp and bone marrow interstitium,with or without leukemic presentation in peripheral blood.3 A standard treatment regimen is not well established,but therapy mostly includes various chemotherapeutic agents.Notably,interferon-α(IFN-α)has been proven to be effective in some patients withγδ-HSTL,but other patients require allogeneic or autologous stem cell transplantation.

关 键 词：hepato SPLENIC INTERFERON 

分 类 号：R733.4[医药卫生—肿瘤]