植物活性成分调节胰岛素分泌机制研究进展  

Research Progress on the Regulation Mechanisms of Insulin Secretion by Plant Active Ingredients

作　　者：张晓云 张薛勤 梅晓宏[1] ZHANG Xiaoyun;ZHANG Xueqin;MEI Xiaohong(Key Laboratory of Safety Assessment of Genetically Modified Organism(Food Safety),Ministry of Agriculture and Rural Affairs,College of Food Science and Nutrition Engineering,China Agricultural University,Beijing 100083,China)

机构地区：[1]中国农业大学食品科学与营养工程学院,农业农村部农业转基因生物安全评价(食用)重点实验室,北京100083

出　　处：《食品工业科技》2021年第16期412-420,共9页Science and Technology of Food Industry

摘　　要：胰腺分泌胰岛素功能障碍是糖尿病重要的病理生理基础,近年来的研究结果表明从植物中提取的活性成分具有调节机体胰岛素分泌的功效,这些活性成分主要包括多糖类、黄酮类、萜类、多酚类、生物碱等。与目前用于临床的口服促胰岛素分泌的降糖药物相比,调控胰岛素分泌的植物活性成分具有毒性低、副作用小的特点,因此,对其降糖功效的研究以及产品开发已引起国内外的广泛关注。本文对近年来天然植物活性成分调节胰岛素分泌的研究模型和作用机制进行综述,以期为天然降血糖产品的开发提供科学参考。The dysfunction of pancreatic insulin secretion is an important pathophysiological basis of diabetes mellitus and the active ingredients extracted from plants have the ability to regulate insulin secretion in the body.These active ingredients mainly include polysaccharides,flavonoids,terpenes,polyphenols,alkaloids and so on.Compared with oral hypoglycemic drugs on insulin secretion,the plant active ingredients regulating insulin secretion has the characteristics of low toxicity and small side effects,which arouses an extensive attention to their hypoglycemic research and development at home and abroad.This paper reviews the research models and regulation mechanisms of insulin secretion by natural plant active ingredients in recent years,which aims to provide scientific reference for the development of nature glucose-lowering products.

关 键 词：糖尿病 植物活性成分 胰岛素 模型 调控机制 

分 类 号：R587.1[医药卫生—内分泌]