微生物法从头合成2-苯乙醇的研究进展  

Recent advances on de novo biosynthesis of 2-phenylethanol

作　　者：朱灵桓 徐沙[1,2] 李由然 张梁[1,2] 石贵阳 ZHU Linghuan;XU Sha;LI Youran;ZHANG Liang;SHI Guiyang(School of Biotechnology,Jiangnan University,Wuxi 214122,China;National Engineering Laboratory for Cereal Fermentation Technology,Jiangnan University,Wuxi 214122,China;College of Food Science and Biology,Hebei University of Science and Technology,Shijiazhuang 050018,China)

机构地区：[1]江南大学生物工程学院,江苏无锡214122 [2]粮食发酵工艺与技术国家工程实验室,江苏无锡214122 [3]河北科技大学食品与生物学院,河北石家庄050018

出　　处：《食品与发酵工业》2021年第16期271-277,共7页Food and Fermentation Industries

基　　金：国家自然科学基金项目(31571817)。

摘　　要：2-苯乙醇具有令人愉悦的玫瑰花香气和良好的理化性质,是一种被广泛应用于食品、医药与日用化工行业的芳香醇。由于市场前景良好,高品质2-苯乙醇产品的需求量逐年上升,绿色高效的微生物发酵制备策略成为近年来的研究热点。该文对微生物中2-苯乙醇的从头合成途径进行了综述,分析了相关的调控机理,并对多种代谢策略进行了评价和展望。2-Phenylethanol is widely used in cosmetics,food and medicine industries owing to its favorable flavors and superior properties.However,the output of pollution-free and high-quality aromatic alcohols remains limited,which make the biosynthesis of 2-phenylethanol gradually become a research hotspot.In this study,the de novo synthetic pathway of 2-phenylethanol is reviewed,relative regulatory mechanism is analyzed,and various metabolic strategies are evaluated and prospected.

关 键 词：2-苯乙醇 从头合成 莽草酸途径 代谢工程 

分 类 号：TQ923[轻工技术与工程—发酵工程]