Bile acids as global regulators of hepatic nutrient metabolism  

作　　者：Phillip B.Hylemon Kazuaki Takabe Mikhail Dozmorov Masayuki Nagahashi Huiping Zhou 

机构地区：[1]Department of Microbiology and Immunology,Medical College of Virginia Campus,Virginia Commonwealth University,Richmond,VA,USA [2]McGuire VA Medical Center,Richmond,VA,USA [3]Department of Surgery,Medical College of Virginia Campus,Virginia Commonwealth University,Richmond,VA,USA [4]Department of Biostatistics,Medical College of Virginia Campus,Virginia Commonwealth University,Richmond,VA,USA [5]Department of Surgery,Niigata University,Japan

出　　处：《Liver Research》2017年第1期10-16,共7页肝脏研究（英文）

基　　金：This work was supported by the US National Institutes of Health(grants R01DK57543 and R01DK104893).

摘　　要：Bile acids(BA)are synthesized from cholesterol in the liver.They are essential for promotion of the absorption of lipids,cholesterol,and lipid-soluble vitamins from the intestines.BAs are hormones that regulate nutrient metabolism by activating nuclear receptors(farnesoid X receptor(FXR),pregnane X receptor,vitamin D)and G protein-coupled receptors(e.g.,TGR5,sphingosine-1-phosphate receptor 2(S1PR2))in the liver and intestines.In the liver,S1PR2 activation by conjugated BAs activates the extracellular signal-regulated kinase 1/2 and AKT signaling pathways,and nuclear sphingosine kinase 2.The latter produces sphingosine-1-phosphate(S1P),an inhibitor of histone deacetylases 1/2,which allows for the differential up-regulation of expression of genes involved in the metabolism of sterols and lipids.We discuss here the emerging concepts of the interactions of BAs,FXR,insulin,S1P signaling and nutrient metabolism.

关 键 词：Sphingosine-1-phosphate Sphingosine kinase 2 Sphingosine-1-phosphate receptor 2 Fatty liver EPIGENETICS 

分 类 号：R57[医药卫生—消化系统]