帕金森病与炎性肠病在遗传学和肠道微生物方面的关联研究进展  

Research progress on the association between Parkinson′s disease and inflammatory bowel disease in genetics and gut microbiota

作　　者：李阳红 周小霞 唐北沙[1,2] Li Yanghong;Zhou Xiaoxia;Tang Beisha(Department of Neurology,Xiangya Hospital,Central South University,Changsha 410008,China;National Clinical Research Center for Geriatric Diseases(Xiangya),Changsha 410008,China)

机构地区：[1]中南大学湘雅医院神经内科,长沙410008 [2]国家老年疾病临床医学研究中心(湘雅),长沙410008

出　　处：《中华神经科杂志》2021年第7期734-742,共9页Chinese Journal of Neurology

基　　金：国家自然科学基金(81430023)。

摘　　要：帕金森病是一种常见的中枢神经系统退行性疾病。在共病研究中发现帕金森病与胃肠道疾病密切关联,两者之间的关系可能涉及“肠-脑轴”紊乱。有遗传学证据和流行病学证据将帕金森病与炎性肠病联系起来。文中将从遗传学证据及“肠-脑轴”的相关概念简述帕金森病和炎性肠病之间的关联。Parkinson′s disease(PD)is a common degenerative disease of central nervous system.PD is closely related to gastrointestinal diseases in comorbidity studies,and the“gut brain axis”disorder may be involved in their relationship.In recent years,relevant studies have suggested that there are genetic and epidemiological evidences to link PD with inflammatory bowel disease(IBD).This article reviews the relationship between PD and IBD from the genetic evidence and the relevant concept of“gut brain axis”.

关 键 词：帕金森病 炎性肠病 LRRK2基因 肠道微生物 肠-脑轴 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R574[医药卫生—临床医学]