Claudin-5介导的BBB功能障碍在脑缺血再灌注中的作用  

The Role of Claudin-5 Mediated BBB Dysfunction in Cerebral Ischemia Reperfusion

作　　者：郭艳芹 赵航 陈静[1] 何治[1] GUO Yanqin;ZHAO Hang;CHEN Jing;HE Zhi(Medical College of Three Gorges University,Yichang 443002,China)

机构地区：[1]三峡大学医学院,宜昌443002

出　　处：《中国细胞生物学学报》2021年第7期1536-1542,共7页Chinese Journal of Cell Biology

基　　金：湖北省卫健委联合基金重点项目(批准号:WJ2019H526);2020年三峡大学研究生学位论文培优基金(批准号:2020SSPY106);天然产物研究与利用湖北省重点实验室开放基金(批准号:NPRD-2018001);国家自然科学基金(批准号:82073824)资助的课题。

摘　　要：Claudin-5为一种跨膜蛋白,是脑内皮细胞间紧密连接的重要黏附分子,参与血脑屏障的组成并调节其通透性和紧密性,参与介导了脑缺血再灌注损伤的发生发展。该文综述了Claudin-5的结构与功能及其在脑缺血再灌注中的作用,为脑缺血再灌注损伤的治疗提供新的理论依据。As a transmembrane protein and an important adhesion molecule of tight junctions between brain endothelial cells,Claudin-5 participates in the composition of the blood-brain barrier and regulates its permeability and tightness.Also it mediates the occurrence and development of cerebral ischemia reperfusion injury.This article reviews the structure and function of Claudin-5,and its role in cerebral ischemia reperfusion,providing a new theoretical basis for the treatment of cerebral ischemia reperfusion injury.

关 键 词：CLAUDIN-5 BBB 脑缺血再灌注 

分 类 号：R743[医药卫生—神经病学与精神病学]