supported by the National Natural Science Foundation of China,No.82104412(to TD);Shaanxi Provincial Key R&D Program,No.2023-YBSF-165(to TD);the Natural Science Foundation of Shaanxi Department of Science and Technology,No.2018JM7022(to FM);Shaanxi Provincial Key Industry Chain Project,No.2021ZDLSF04-11(to PW)。
The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the bloo...
Recently,a novel radiotracer,[^(18)F]QTFT,synthesized by Li's group1 and published in Acta Pharmaceutica Sinica B,was identified as a PET tracer capable of specifically visualize the anti-inflammatory microglia target...
Brain metastasis and primary glioblastoma multiforme represent the most common and lethal malignant brain tumors.Its median survival time is typically less than a year after diagnosis.One of the major challenges in tr...
supported by the National Natural Science Foundation of China(Nos.82174010 and 81973512).
The blood-brain barrier(BBB)is a highly selective and critical interface between the blood and the central nervous system(CNS),essential for maintaining the microenvironment necessary for normal brain function and hom...
the Research and Development Program of Science and Technology Department of Sichuan Province(2022JDJQ0050);111 Project(B18035);the Fundamental of Research Funds for the Central Universities.
Inflammatory responses,manifested in excessive oxidative stress and microglia overactivation,together with metal ion-triggered amyloid-beta(Aβ)deposition,are critical hallmarks of Alzheimer’s disease(AD).The intrica...