Illuminating Neural Circuits in Alzheimer’s Disease  

作　　者：Yang Ying Jian-Zhi Wang 

机构地区：[1]Department of Pathophysiology,School of Basic Medicine,Ministry of Education Key Laboratory for Neurological Disorders,Hubei Key Laboratory for Neurological Disorders,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China

出　　处：《Neuroscience Bulletin》2021年第8期1203-1217,共15页神经科学通报（英文版）

基　　金：Grants from the Natural Science Foundation of China(31730035,82071219,91632305,and 91949205);the Ministry of Science and Technology of China(2016YFC1305800);the Guangdong Provincial Key S&T Program(2018B030336001).

摘　　要：Alzheimer’s disease(AD)is the most common neurodegenerative disorder and there is currently no cure.Neural circuit dysfunction is the fundamental mechanism underlying the learning and memory deficits in patients with AD.Therefore,it is important to understand the structural features and mechanisms underlying the deregulated circuits during AD progression,by which new tools for intervention can be developed.Here,we briefly summarize the most recently established cutting-edge experimental approaches and key techniques that enable neural circuit tracing and manipulation of their activity.We also discuss the advantages and limitations of these approaches.Finally,we review the applications of these techniques in the discovery of circuit mechanisms underlyingβ-amyloid and tau pathologies during AD progression,and as well as the strategies for targeted AD treatments.

关 键 词：Neural circuit Alzheimer’s disease Single cell RNA sequencing Neural circuit tracing OPTOGENETICS Chemogenetics 

分 类 号：R749.16[医药卫生—神经病学与精神病学]