Update on molecular diversity and multipathogenicity of staphylococcal superantigen toxins  

作　　者：Dongliang Hu Shaowen Li Rendong Fang Ono K.Hisaya 

机构地区：[1]Department of Zoonoses,Kitasato University School of Veterinary Medicine,Towada 034-8628,Japan [2]College of Veterinary Medicine,Huazhong Agricultoral University,Wuhan 430070,People's Republic of China [3]College of Veterinary Medicine,Southwest University,Congqing 400715,People's Republic of China

出　　处：《Animal Diseases》2021年第2期69-83,共15页动物疾病（英文）

基　　金：This study was supported in part by the JSPS KAKENHI Grant numbers 19590438(D.H.);21590475(D.H.);24590516(D.H.);16H05030(D.H.).

摘　　要：Staphylococcal superantigen(SAg)toxins are the most notable virulence factors associated with Staphylococcus aureus,which is a pathogen associated with serious community and hospital acquired infections in humans and various diseases in animals.Recently,SAg toxins have become a superfamily with 29 types,including staphylococcal enterotoxins(SEs)with emetic activity,SE-like toxins(SEIs)that do not induce emesis in primate models or have yet not been tested,and toxic shock syndrome toxin-1(TSST-1).SEs and SEIs can be subdivided into classical types(SEA to SEE)and novel types(SEG to SEIY,SE01,SE02,SEI26 and SEI27).The genes of SAg toxins are located in diverse accessory genetic elements and share certain structural and biological properties.SAg toxins are heat-stable proteins that exhibit pyrogenicity,superantigenicity and capacity to induce lethal hypersensitivity to endotoxin in humans and animals.They have multiple pathogenicities that can interfere with normal immune function of host,increase the chances of survival and transmission of pathogenic baaeria in host,consequently contribute to the occurrence and development of various infeaions,persistent infeaions or food poisoning.This review focuses on the following aspeas of SAg toxins:(1)superfamily members of classic and novelty discovered staphylococcal SAgs;⑵diversity of gene locations and molecular structural characteristics;(3)biological characteristics and activities;(4)multi-pathogenicity of SAgs in animal and human diseases,including bovine mastitis,swine sepsis,abscesses and skin edema in pig,arthritis and septicemia in poultry,and nosocomial infections and food-borne diseases in humans.

关 键 词：Staphylococcus aureus SUPERANTIGEN ENTEROTOXIN Pathogenecity Food poisoning Infeaion 

分 类 号：R73[医药卫生—肿瘤]