乳酸/HCAR1信号系统的生物学功能研究进展  

Research progress in the biological function of lactate/HCAR1 signaling system

作　　者：帅念念 周佳秀(综述) 田绍文 王波[1] 旷昕(审校)[1,3] SHUAI Niannian;ZHOU Jiaxiu;TIAN Shaowen;WANG Bo;KUANG Xin(Department of Anesthesiology,First Affiliated Hospital of University of South China,Hengyang Hunan 421001;Guangxi Key Laboratory of Brain and Congnitive Neuroscience,Faculty of Basic Medical Sciences,Guilin Medical University,Guilin Guangxi 541001;Department of Anesthesiology,Longhua People’s Hospital,Southern Medical University,Shenzhen Guangdong 518109,China)

机构地区：[1]南华大学附属第一医院麻醉科,湖南衡阳421001 [2]桂林医学院基础医学院广西脑与认知神经科学重点实验室,广西桂林541001 [3]南方医科大学附属龙华区人民医院麻醉科,广东深圳518109

出　　处：《临床与病理杂志》2021年第8期1925-1931,共7页Journal of Clinical and Pathological Research

基　　金：湖南省自然科学基金(2018JJ3465)。

摘　　要：羟基羧酸受体1(hydroxy-carboxylic acid receptor 1,HCAR1)是一种孤儿G蛋白耦联受体,也是乳酸的特异性受体,广泛分布于中枢和外周组织。近年来,越来越多的研究表明,乳酸/HCAR1信号系统在机体发挥重要作用。乳酸/HCAR1信号系统通过激活下游信号通路,参与内分泌系统、心血管系统、神经系统、免疫系统、肿瘤等相关系统疾病的发生和发展过程。Hydroxy-carboxylic acid receptor 1(HCAR1)is an orphan G protein-coupled receptor and a specific receptor for lactate,which is widely distributed in central and peripheral tissues.In recent years,more and more studies have shown that lactate/HCAR1 signaling system plays an important role in the body.By activating the downstream signaling pathway,the lactate/HCAR1 signaling system is involved in the occurrence and development of diseases related to endocrine system,cardiovascular system,nervous system,immune system,tumors,etc.

关 键 词：乳酸 羟基羧酸受体1 GPR81 内分泌系统 神经系统 肿瘤 

分 类 号：R363[医药卫生—病理学]