Pathomolecular characterization of HCC in non-cirrhotic livers  

作　　者：Archana Rastogi 

机构地区：[1]Department of Pathology,Institute of Liver&Biliary Sciences,New Delhi-110070,India.

出　　处：《Hepatoma Research》2020年第8期12-28,共17页肝癌研究（英文版）

摘　　要：Hepatocellular carcinoma(HCC)is the most common primary liver cancer and usually arises in cirrhotic livers.Increasingly,it is diagnosed in non-cirrhotic livers.A variety of risk factors and etiologies can trigger the development of HCC in non-fibrotic and non-cirrhotic backgrounds.The most important causes are metabolic syndrome and hepatitis B virus infection.Postulated pathogenetic mechanisms are direct carcinogenesis,chronic liver injury and repair cycles,and genetic/epigenetic aberrations.Histopathology has a very important role in the diagnosis of non-cirrhotic HCC.Gross features of non-cirrhotic HCC are quite different from HCC originating in a cirrhotic background.Microscopic characteristics are similar to a classical HCC.However,certain histological variants show a predilection to occur in non-cirrhotic livers.These encompass fibrolamellar,scirrhous,steatohepatitic and mixed hepato-cholangiocarcinoma subtypes.Due to the non-cirrhotic background,adenoma,metastasis and most of the other non-neoplastic and neoplastic conditions enter the differential diagnosis.Genomic studies and morpho-molecular classifications of HCC provide further understanding of the molecular pathogenesis of non-cirrhotic HCC.This group however,has rarely been exclusively studied.This review offers an update of etiology,patho-molecular characteristics and differential diagnosis of HCC arising in non-cirrhotic backgrounds.

关 键 词：Hepatocellular carcinoma non-cirrhotic ETIOPATHOGENESIS molecular genetics PATHOLOGY patho-molecular differential diagnosis 

分 类 号：R73[医药卫生—肿瘤]