机器人辅助定位平阳霉素注射治疗口腔颌面部脉管畸形的研究与应用  

The research and application of robot assisted positioning Pingyangmycin injection in the treatment of vascular malformation in oral and maxillofacial region

作　　者：邢乐君[1] 陈飞[1] 贾婷婷[1] 孟凡皓 周正 乔波 朱亮 赵睿[1] 张海钟[1] XING Lejun;CHEN Fei;JIA Tingling;MENG Fanhao;ZHOU Zheng;QIAO Bo;ZHU Liang;ZHAO Rui;ZHANG Haizhong(Department of Stomatology,First Medical Center,PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心口腔科,北京100853

出　　处：《口腔医学》2021年第8期699-703,共5页Stomatology

基　　金：科技部重大专项国家重点研发计划(2017YFB1304300)。

摘　　要：目的观察并研究机器人辅助定位下平阳霉素注射治疗口腔颌面部脉管畸形的临床疗效。方法收集2017—2021年本院收治的有完整临床资料的共20例口腔颌面颈部脉管畸形患者进行回顾性分析,所有患者均采用机器人辅助定位平阳霉素药物注射治疗,观察并记录患者预后情况,复查颌面部增强CT或者MRI评价瘤体大小变化作为疗效评价指标。结果 20例患者均在机器人辅助下顺利完成手术,临床有效率95%,术后无药物不良反应发生。该技术手术安全性良好,充分发挥机器人定位准确的优势,采用退针给药的方法增强药物与脉管畸形病变内皮细胞作用面积,充分发挥药物治疗作用,缩短平阳霉素药物注射间隔时间。结论机器人辅助定位并平阳霉素药物注射治疗脉管畸形安全有效,创伤小,精度高,可重复注射治疗,最大程度保留原始器官外形及功能发挥,临床应用价值高。Objective To observe and study the clinical effect of Pingyangmycin injection under robot assisted localization in the treatment of vascular malformations in oral and maxillofacial region.Methods A total of 20 patients with vascular malformations in oral,maxillofacial and cervical region who had complete clinical data in our hospital from 2017 to 2021 were collected and analyzed retrospectively.All patients were treated with Pingyangmycin injection assisted by robot localization.The prognosis of patients was observed and recorded.The changes of tumor size were evaluated by maxillofacial enhanced CT or MRI as the evaluation index of curative effect.Results All the 20 patients successfully completed the operation with the assistance of robot.The clinical effective rate was 95%,and there was no adverse drug reaction after the operation.This technique has good safety,gives full play to the advantages of accurate robot positioning,enhances the interaction area between drugs and vascular malformation endothelial cells by using the method of needle withdrawal administration,gives full play to the role of drug therapy,and shortens the interval time of Pingyangmycin drug injection.Conclusion Robot assisted localization and Pingyangmycin drug injection in the treatment of vascular malformation is safe and effective,with small trauma and high precision,which can accept repeatable injection treatment and achieve the maximum preservation of the original organ shape and function,and has high clinical application value.

关 键 词：机器人 平阳霉素 口腔颌面部 脉管畸形 机器人辅助定位 

分 类 号：R739.8[医药卫生—肿瘤]