Overview on drug-induced liver injury in Brazil  

作　　者：Fernando Bessone 

机构地区：[1]Department of Gastroenterology and Hepatology,Hospital Provincial del Centenario,Facultad de Ciencias Médicas,University of Rosario School of Medicine,Rosario 2000,Santa Fe,Argentina

出　　处：《World Journal of Gastrointestinal Pharmacology and Therapeutics》2021年第5期100-102,共3页世界胃肠药理与治疗学杂志（英文版）（电子版）

摘　　要：Drug-induced liver injury(DILI)is an uncommon event in clinical practice,which makes knowing its true incidence difficult.Prospective,retrospective and registry-based studies are the most important methods to obtain epidemiological data on DILI.Latin America(LA)has a historical lack of prospective studies on this topic.New definitions and the creation of hepatotoxicity registries have significantly improved the epidemiological understanding of hepatic drug reactions in several regions of the world.The Latin American DILI network,referred to as LATINDILI,has been created in 2011,and recently published its own DILI recommendations describing the most relevant issues on the management of hepatotoxicity in general,and those based on findings from our own LA experience in particular.Although most of the registries do not carry out population-based studies,they may provide important data related to the prevalence of DILI.The joint work among researchers and the corresponding health and regulatory authorities should be stimulated due to the high impact that hepatotoxicity represents for public health.

关 键 词：HEPATOTOXICITY Drug-induced liver injury Drug-induced liver injury registries HERBS HEPATITIS 

分 类 号：R575[医药卫生—消化系统]