Primary gastric non-Hodgkin lymphomas:Recent advances regarding disease pathogenesis and treatment  

作　　者：Michael D Diamantidis Maria Papaioannou Evdoxia Hatjiharissi 

机构地区：[1]Department of Hematology,Thalassemia and Sickle Cell Disease Unit,General Hospital of Larissa,Larissa 41221,Thessaly,Greece [2]Division of Hematology,First Department of Internal Medicine,AHEPA General Hospital,Aristotle University of Thessaloniki,Thessaloniki 54636,Greece

出　　处：《World Journal of Gastroenterology》2021年第35期5932-5945,共14页世界胃肠病学杂志（英文版）

摘　　要：Primary gastric lymphomas(PGLs)are distinct lymphoproliferative neoplasms described as heterogeneous entities clinically and molecularly.Their main histological types are diffuse large B-cell lymphoma(DLBCL)or mucosaassociated lymphoma tissue.PGL has been one of the main fields of clinical research of our group in recent years.Although gastric DLBCLs are frequent,sufficient data to guide optimal care are scarce.Until today,a multidisciplinary approach has been applied,including chemotherapy,surgery,radiotherapy or a combination of these treatments.In this minireview article,we provide an overview of the clinical manifestations,diagnosis and staging of these diseases,along with their molecular pathogenesis and the most important related clinical published series.We then discuss the scientific gaps,perils and pitfalls that exist regarding the aforementioned studies,in parallel with the unmet need for future research and comment on the proper methodology for such retrospective studies.Aiming to fill this gap,we retrospectively evaluated the trends in clinical presentation,management and outcome among 165 patients with DLBCL PGL who were seen in our institutions in 1980-2014.The study cohort was divided into two subgroups,comparing the main 2 therapeutic options[cyclophosphamide doxorubicin vincristine prednisone(CHOP)vs rituximab-CHOP(R-CHOP)].A better outcome with immunochemotherapy(R-CHOP)was observed.In the next 2 mo,we will present the update of our study with the same basic conclusion.

关 键 词：Primary gastric lymphoma Extranodal non-Hodgkin’s lymphoma Diffuse large B-cell lymphoma Mucosa-associated lymphoid tissue IMMUNOCHEMOTHERAPY Rituximab-cyclophosphamide doxorubicin vincristine prednisone 

分 类 号：R735.2[医药卫生—肿瘤]